Comparison of incidence of grades 3/4 nonhematological toxicities among randomized patients with and without DS
| . | Induction DS/non-DS, % . | P . | Consolidation DS/non-DS, % . | P . | IM-1 DS/ non-DS, % . | P . | DI-1 DS/ non-DS, % . | P . | IM-2 DS/ non-DS, % . | P . | DI-2 DS/ non-DS, % . | P . | Maintenance DS/non-DS, % . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular | 2.7/5.0 | .65 | 1.3/1.2 | .88 | 2.7/0.6 | .032 | 1.4/1.1 | .80 | 0/0 | — | 0/1.2 | .56 | 3.0/0.8 | .045 |
| Coagulation | 5.3/6.0 | .47 | 0/0.5 | .54 | 1.4/0.1 | .002 | 0/1.7 | .26 | 0/0 | — | 0/1.7 | .78 | 1.5/0.5 | .25 |
| Gastrointestinal* | 4.0/5.8 | .56 | 6.7/4.0 | .48 | 16.2/3.6 | <.001 | 16.4/7.0 | .007 | 20.3/4.2 | <.001 | 17.9/7.7 | .13 | 15.2/6.7 | .027 |
| Hepatic | 10.7/7.2 | .52 | 16.0/10.8 | .17 | 16.2/12.9 | .38 | 9.6/4.8 | .078 | 10.1/11.7 | .92 | 3.6/6.0 | .84 | 25.8/31.2 | .14 |
| Infection/febrile neutropenia | 14.7/15.3 | .84 | 18.7/9.9 | .014 | 12.2/8.3 | .46 | 28.8/23.9 | .43 | 11.6/8.5 | .37 | 32.1/26.4 | .73 | 50.0/42.1 | .26 |
| Neurology | 2.7/5.1 | .60 | 6.7/4.2 | .19 | 4.1/3.6 | .88 | 1.4/2.9 | .73 | 2.9/1.9 | .82 | 7.1/3.0 | .36 | 7.6/3.8 | .18 |
| Renal/genitourinary | 0/0.5 | .83 | 0/0.4 | .88 | 0/0.1 | .85 | 0/0.2 | .95 | 0/0.1 | .85 | 0/0.2 | .81 | 0/0.3 | .64 |
| . | Induction DS/non-DS, % . | P . | Consolidation DS/non-DS, % . | P . | IM-1 DS/ non-DS, % . | P . | DI-1 DS/ non-DS, % . | P . | IM-2 DS/ non-DS, % . | P . | DI-2 DS/ non-DS, % . | P . | Maintenance DS/non-DS, % . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular | 2.7/5.0 | .65 | 1.3/1.2 | .88 | 2.7/0.6 | .032 | 1.4/1.1 | .80 | 0/0 | — | 0/1.2 | .56 | 3.0/0.8 | .045 |
| Coagulation | 5.3/6.0 | .47 | 0/0.5 | .54 | 1.4/0.1 | .002 | 0/1.7 | .26 | 0/0 | — | 0/1.7 | .78 | 1.5/0.5 | .25 |
| Gastrointestinal* | 4.0/5.8 | .56 | 6.7/4.0 | .48 | 16.2/3.6 | <.001 | 16.4/7.0 | .007 | 20.3/4.2 | <.001 | 17.9/7.7 | .13 | 15.2/6.7 | .027 |
| Hepatic | 10.7/7.2 | .52 | 16.0/10.8 | .17 | 16.2/12.9 | .38 | 9.6/4.8 | .078 | 10.1/11.7 | .92 | 3.6/6.0 | .84 | 25.8/31.2 | .14 |
| Infection/febrile neutropenia | 14.7/15.3 | .84 | 18.7/9.9 | .014 | 12.2/8.3 | .46 | 28.8/23.9 | .43 | 11.6/8.5 | .37 | 32.1/26.4 | .73 | 50.0/42.1 | .26 |
| Neurology | 2.7/5.1 | .60 | 6.7/4.2 | .19 | 4.1/3.6 | .88 | 1.4/2.9 | .73 | 2.9/1.9 | .82 | 7.1/3.0 | .36 | 7.6/3.8 | .18 |
| Renal/genitourinary | 0/0.5 | .83 | 0/0.4 | .88 | 0/0.1 | .85 | 0/0.2 | .95 | 0/0.1 | .85 | 0/0.2 | .81 | 0/0.3 | .64 |
—, not calculated.
Differences in incidence mainly due to mucositis.