Table 1.

Interim maintenance regimens

Oral methotrexate regimenIV methotrexate regimen
Vincristine: 1.5 mg/m2 days 0 and 28 Vincristine: 1.5 mg/m2 (maximum, 2 mg) every 10 d × 5 
Dexamethasone: PO 6 mg/m2/d days 0-4 and days 28-32 Methotrexate: initial dose: 100 mg/m2 escalate by 50 mg/m2 per toxicity parameters every 10 d × 5 
Methotrexate: PO 20 mg/m2 weekly × 8 Methotrexate intrathecal day 30 
Mercaptopurine: PO 75 mg/m2/d days 0-49  
Methotrexate: intrathecal day 28  
Oral methotrexate regimenIV methotrexate regimen
Vincristine: 1.5 mg/m2 days 0 and 28 Vincristine: 1.5 mg/m2 (maximum, 2 mg) every 10 d × 5 
Dexamethasone: PO 6 mg/m2/d days 0-4 and days 28-32 Methotrexate: initial dose: 100 mg/m2 escalate by 50 mg/m2 per toxicity parameters every 10 d × 5 
Methotrexate: PO 20 mg/m2 weekly × 8 Methotrexate intrathecal day 30 
Mercaptopurine: PO 75 mg/m2/d days 0-49  
Methotrexate: intrathecal day 28  
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