Characteristics of patients with MLL-rearranged AML and CCND3 mutation
| Sample ID . | Age, y . | Sex . | Karyotype . | Exonic function . | AA change . | Mismatch rate . | Relapse . | Death . |
|---|---|---|---|---|---|---|---|---|
| Childhood AML | ||||||||
| AML05-120 | 11 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.401 | − | − |
| AML05-206 | 7 | F | MLL-MLLT3 | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.045 | + | + |
| AML05-213 | 0 | M | MLL-MLLT10 | Frameshift insertion | exon5:c.836_837insAG p.S279fs | 0.105 | − | − |
| AML05-422 | 5 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.479 | + | − |
| AML05-426 | 1 | F | MLL-MLLT1 | Frameshift deletion | exon5:c.754_755delAG p.R252fs | 0.022 | − | − |
| Frameshift insertion | exon5:c.757dupG p.E253fs | 0.063 | ||||||
| Frameshift insertion | exon5:c.811dupC p.R271fs | 0.040 | ||||||
| Missense SNV | exon5:c.C851G p.P284R | 0.286 | ||||||
| Adult AML | ||||||||
| OT-034 | 66 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.431 | N/A | N/A |
| 07H003* | 25 | F | MLL-ELL | Frameshift insertion | exon5:c.806dupC p.A269fs | 0.282 | N/A | N/A |
| Sample ID . | Age, y . | Sex . | Karyotype . | Exonic function . | AA change . | Mismatch rate . | Relapse . | Death . |
|---|---|---|---|---|---|---|---|---|
| Childhood AML | ||||||||
| AML05-120 | 11 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.401 | − | − |
| AML05-206 | 7 | F | MLL-MLLT3 | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.045 | + | + |
| AML05-213 | 0 | M | MLL-MLLT10 | Frameshift insertion | exon5:c.836_837insAG p.S279fs | 0.105 | − | − |
| AML05-422 | 5 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.479 | + | − |
| AML05-426 | 1 | F | MLL-MLLT1 | Frameshift deletion | exon5:c.754_755delAG p.R252fs | 0.022 | − | − |
| Frameshift insertion | exon5:c.757dupG p.E253fs | 0.063 | ||||||
| Frameshift insertion | exon5:c.811dupC p.R271fs | 0.040 | ||||||
| Missense SNV | exon5:c.C851G p.P284R | 0.286 | ||||||
| Adult AML | ||||||||
| OT-034 | 66 | M | MLL-ELL | Frameshift insertion | exon5:c.811dupC p.R271fs | 0.431 | N/A | N/A |
| 07H003* | 25 | F | MLL-ELL | Frameshift insertion | exon5:c.806dupC p.A269fs | 0.282 | N/A | N/A |
AA, amino acid; F, female; M, male; N/A, not available.
Data for 07H003 were obtained by reanalysis of RNA-sequencing data reported in a previous study.18