Adverse events with possible or probable relationship to eculizumab treatment
| Severity/possibly related to treatment . | Probably related to treatment . |
|---|---|
| Severe | |
| Peritonitis* | Pneumonia† |
| Moderate | |
| Hemorrhoidal hemorrhage* | - - - |
| Fatigue‡ | |
| Muscle cramps‡ | |
| Arterial stenosis‡ | |
| Hypertension | |
| Pruritus | |
| Urinary tract infection | |
| Mild | |
| Limb pain‡ | - - - |
| Oral herpes infection | |
| Fatigue | |
| Creatinine increase (2 episodes) |
| Severity/possibly related to treatment . | Probably related to treatment . |
|---|---|
| Severe | |
| Peritonitis* | Pneumonia† |
| Moderate | |
| Hemorrhoidal hemorrhage* | - - - |
| Fatigue‡ | |
| Muscle cramps‡ | |
| Arterial stenosis‡ | |
| Hypertension | |
| Pruritus | |
| Urinary tract infection | |
| Mild | |
| Limb pain‡ | - - - |
| Oral herpes infection | |
| Fatigue | |
| Creatinine increase (2 episodes) |
Patient 9 with preexisting liver cirrhosis and clinical suspicion of spontaneous peritonitis (no bacterial pathogen demonstrated).
Full recovery without delay of eculizumab administration (patient 14).
Patient 11 with preexisting atherosclerosis and atrial fibrillation, pain in left foot, and cramps in left calf starting in the first month of eculizumab therapy, diagnosis of a stenosis of the left superficial femoral artery in the posttreatment phase.