Univariate analysis of association with graft failure
| Univariate analysis . | Actuarial probability (%) . | P value . |
|---|---|---|
| Donor's sex (male vs female) | 8 vs 14.5 | .2 |
| Recipient's sex (male vs female) | 12 vs 10.5 | .9 |
| Sex-pairing mismatched (no vs yes) | 8 vs 15 | .16 |
| Female D to Male R (no vs yes) | 9 vs 19.5 | .11 |
| Male D to Female R (no vs yes) | 11.5 vs 11 | .99 |
| Donor's median age (≤ 40 y vs > 40 y) | 13 vs 11 | .5 |
| Recipient's median age (≤ 42 y vs. > 42 y) | 10 vs 12.5 | .7 |
| ABO incompatibility (no vs yes) | 12.5 vs 9 | .64 |
| Median CD34+ cells × 106/kg (≤ 3.6 vs > 3.6) | 12.6 vs 9.9 | .44 |
| Mean CD34+ cells × 106/kg (≤ 4 vs > 4) | 12.6 vs 9.3 | .43 |
| CD34+ cells × 106/kg in quartiles | ||
| ≤ 2.5 | 10.6 | |
| > 2.5 to 3.6 | 13 | |
| > 3.6 to 5 | 12.6 | |
| > 5 | 9.1 | |
| log-rank χ2 = 0.3 | .95 | |
| log-rank for trend χ2 = 0.1 | .75 | |
| Median CD3+ cells × 106/kg (≤ 0.12 vs > 0.12) | 18 vs 4 | .002 |
| Mean CD3+ cells × 106/kg (≤ 0.28 vs > 0.28) | 16 vs 1.5 | .001 |
| CD3+ cells × 106/kg in quartiles | ||
| ≤ 0.07 | 18.5 | |
| > 0.07 to 0.12 | 16.1 | |
| > 0.12 to 0.37 | 8.3 | |
| > 0.37 | 2.1 | |
| log-rank χ2= 8.5 | .03 | |
| log-rank for trend χ2 = 8.5 | .003 | |
| CD3+ cells × 106/kg (≤ 0.2 vs > 0.2) | 18 vs 1 | .0001 |
| Conditioning regimen (TBI vs Bu) | 8 vs 18 | .04 |
| Stage of disease (early vs advanced) | 12 vs 19 | .7 |
| Cryopreservation (no vs yes) | 8 vs 18 | .03 |
| Diagnosis (CML vs others) | 21 vs 8 | .007 |
| CML + Bu (no vs yes) | 7.5 vs 32 | .0008 |
| Univariate analysis . | Actuarial probability (%) . | P value . |
|---|---|---|
| Donor's sex (male vs female) | 8 vs 14.5 | .2 |
| Recipient's sex (male vs female) | 12 vs 10.5 | .9 |
| Sex-pairing mismatched (no vs yes) | 8 vs 15 | .16 |
| Female D to Male R (no vs yes) | 9 vs 19.5 | .11 |
| Male D to Female R (no vs yes) | 11.5 vs 11 | .99 |
| Donor's median age (≤ 40 y vs > 40 y) | 13 vs 11 | .5 |
| Recipient's median age (≤ 42 y vs. > 42 y) | 10 vs 12.5 | .7 |
| ABO incompatibility (no vs yes) | 12.5 vs 9 | .64 |
| Median CD34+ cells × 106/kg (≤ 3.6 vs > 3.6) | 12.6 vs 9.9 | .44 |
| Mean CD34+ cells × 106/kg (≤ 4 vs > 4) | 12.6 vs 9.3 | .43 |
| CD34+ cells × 106/kg in quartiles | ||
| ≤ 2.5 | 10.6 | |
| > 2.5 to 3.6 | 13 | |
| > 3.6 to 5 | 12.6 | |
| > 5 | 9.1 | |
| log-rank χ2 = 0.3 | .95 | |
| log-rank for trend χ2 = 0.1 | .75 | |
| Median CD3+ cells × 106/kg (≤ 0.12 vs > 0.12) | 18 vs 4 | .002 |
| Mean CD3+ cells × 106/kg (≤ 0.28 vs > 0.28) | 16 vs 1.5 | .001 |
| CD3+ cells × 106/kg in quartiles | ||
| ≤ 0.07 | 18.5 | |
| > 0.07 to 0.12 | 16.1 | |
| > 0.12 to 0.37 | 8.3 | |
| > 0.37 | 2.1 | |
| log-rank χ2= 8.5 | .03 | |
| log-rank for trend χ2 = 8.5 | .003 | |
| CD3+ cells × 106/kg (≤ 0.2 vs > 0.2) | 18 vs 1 | .0001 |
| Conditioning regimen (TBI vs Bu) | 8 vs 18 | .04 |
| Stage of disease (early vs advanced) | 12 vs 19 | .7 |
| Cryopreservation (no vs yes) | 8 vs 18 | .03 |
| Diagnosis (CML vs others) | 21 vs 8 | .007 |
| CML + Bu (no vs yes) | 7.5 vs 32 | .0008 |
F indicates female; M, male; D, donor; R, recipient; TBI, total body irradiation; Bu, busulphan; CML, chronic myeloid leukemia.