Table 1. Amino acid residues at which... | American Society of Hematology

Table 1.

Amino acid residues at which extracellular domains of GPIIb, GPIIIa, and GPIbα are predicted to differ among 4 mouse strains

	GPIIb*							GPIIIa*
Mouse strain	37	111	179	392	805	933	976	103	297	677	323	374	381	382	422	429	432	444	459	490	493	496	545
C57	E	G	A	P	R	V	R	A	H	A	A	K	P	S	T	H	I	K	L	T	H	T	T
129	—	—	—	—	S	A	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
PWK	V	—	—	—	S	A	Q	S	—	—	—	—	T	—	—	—	—	—	—	N	P	—	I
SPRET	—	S	D	S	S	A	—	—	R	S	T	E	T	T	A	P	T	E	P	N	—	I	—

	GPIIb*							GPIIIa*
Mouse strain	37	111	179	392	805	933	976	103	297	677	323	374	381	382	422	429	432	444	459	490	493	496	545
C57	E	G	A	P	R	V	R	A	H	A	A	K	P	S	T	H	I	K	L	T	H	T	T
129	—	—	—	—	S	A	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—
PWK	V	—	—	—	S	A	Q	S	—	—	—	—	T	—	—	—	—	—	—	N	P	—	I
SPRET	—	S	D	S	S	A	—	—	R	S	T	E	T	T	A	P	T	E	P	N	—	I	—

— indicates identity with C57.

Numbers denote amino acid positions at which extracellular domains of GPIIb, GPIIIa, and GPIbα of the 4 mouse strains differ from one another. C57 was chosen as the reference strain. Letters assigned to the other 3 strains indicate amino acids that differ from C57. Amino acid 1 starts with the ATG of the translation start codon for each of the expressed proteins. Amino acids are designated by the conventional letter code. No intracellular polymorphisms have been reported in these glycoproteins.

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