Toxicities grade 3 or higher according to MedDRA category coding plus fever in neutropenia during first induction therapy
| . | All patients (n = 284) . | Younger, 18-60 yr (n = 198) . | Older, 61-70 yr (n = 86) . | P . |
|---|---|---|---|---|
| Infection, n (%) | 168 (59) | 118 (60) | 50 (58) | .90 |
| Febrile neutropenia, n (%) | 100 (35) | 69 (35) | 31 (36) | .89 |
| Gastrointestinal, n (%) | 70 (25) | 45 (23) | 25 (29) | .46 |
| Metabolic/Laboratory, n (%) | 61 (21) | 44 (22) | 17 (20) | .75 |
| Cardiac total, n (%) | 37 (13) | 18 (6) | 19 (22) | .004 |
| Cardiac general, n (%) | 21 (7) | 11 (4) | 10 (12) | .09 |
| Cardiac arrhythmia, n (%) | 16 (6) | 7 (2) | 9 (10) | .03 |
| Pulmonary/upper respiratory, n (%) | 25 (9) | 13 (7) | 12 (14) | .07 |
| Pain, n (%) | 23 (8) | 17 (9) | 6 (7) | .81 |
| Constitutional, n (%) | 18 (6) | 12 (6) | 6 (7) | .79 |
| Renal/Genitourinary, n (%) | 17 (6) | 13 (7) | 4 (5) | .79 |
| Hemorrhage/bleeding, n (%) | 17 (6) | 9 (5) | 8 (9) | .17 |
| Hepatobiliary/pancreas, n (%) | 8 (3) | 5 (3) | 3 (3) | .71 |
| Neurologic, n (%) | 9 (3) | 6 (3) | 3 (3) | .99 |
| Rash, n (%) | 5 (2) | 4 (2) | 1 (1) | .99 |
| Other, n (%) | 18 (6) | 10 (5) | 8 (9) | .19 |
| . | All patients (n = 284) . | Younger, 18-60 yr (n = 198) . | Older, 61-70 yr (n = 86) . | P . |
|---|---|---|---|---|
| Infection, n (%) | 168 (59) | 118 (60) | 50 (58) | .90 |
| Febrile neutropenia, n (%) | 100 (35) | 69 (35) | 31 (36) | .89 |
| Gastrointestinal, n (%) | 70 (25) | 45 (23) | 25 (29) | .46 |
| Metabolic/Laboratory, n (%) | 61 (21) | 44 (22) | 17 (20) | .75 |
| Cardiac total, n (%) | 37 (13) | 18 (6) | 19 (22) | .004 |
| Cardiac general, n (%) | 21 (7) | 11 (4) | 10 (12) | .09 |
| Cardiac arrhythmia, n (%) | 16 (6) | 7 (2) | 9 (10) | .03 |
| Pulmonary/upper respiratory, n (%) | 25 (9) | 13 (7) | 12 (14) | .07 |
| Pain, n (%) | 23 (8) | 17 (9) | 6 (7) | .81 |
| Constitutional, n (%) | 18 (6) | 12 (6) | 6 (7) | .79 |
| Renal/Genitourinary, n (%) | 17 (6) | 13 (7) | 4 (5) | .79 |
| Hemorrhage/bleeding, n (%) | 17 (6) | 9 (5) | 8 (9) | .17 |
| Hepatobiliary/pancreas, n (%) | 8 (3) | 5 (3) | 3 (3) | .71 |
| Neurologic, n (%) | 9 (3) | 6 (3) | 3 (3) | .99 |
| Rash, n (%) | 5 (2) | 4 (2) | 1 (1) | .99 |
| Other, n (%) | 18 (6) | 10 (5) | 8 (9) | .19 |
MedRA, Medical Dictionary for Regulatory Activities.