Multivariate analyses for OS, NRM, and relapse
| Variable . | n (%) . | Hazard ratio (95% CI) . | P . |
|---|---|---|---|
| OS | |||
| Age, y | |||
| <65 | 454 (74) | Reference | – |
| ≥65 | 158 (26) | 1.53 (1.19-1.96) | .0008 |
| Comorbidity index | |||
| HCT-CI < 3 | 403 (66) | Reference | – |
| HCT-CI ≥ 3 | 209 (34) | 1.19 (0.94-1.51) | .154 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 1.12 (0.89-1.43) | .338 |
| HLA-MMUD | 89 (15) | 1.20 (0.87-1.66) | .273 |
| DRI | |||
| Low | 140 (23) | Reference | – |
| Intermediate | 289 (47) | 1.46 (1.08-1.98) | .015 |
| High or very high | 183 (30) | 2.66 (1.94-3.66) | <.0001 |
| NRM | |||
| Age, y | |||
| <65 | 454 (74) | Reference | – |
| ≥65 | 158 (26) | 1.32 (0.80-2.16) | .270 |
| Comorbidity index | |||
| HCT-CI < 3 | 403 (66) | Reference | – |
| HCT-CI ≥ 3 | 209 (34) | 1.53 (0.99-2.35) | .056 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 1.78 (1.09-2.91) | .022 |
| HLA-MMUD | 89 (15) | 3.23 (1.88-5.57) | .0002 |
| Relapse | |||
| DRI | |||
| Low | 140 (23) | Reference | – |
| Intermediate | 289 (47) | 1.27 (0.95-1.69) | .11 |
| High or very high | 183 (30) | 1.77 (1.28-2.44) | .005 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 0.96 (0.75-1.23) | .75 |
| HLA-MMUD | 89 (15) | 0.68 (0.44-1.06) | .085 |
| Donor and recipient sex matching | |||
| Sex matched | 308 (50) | Reference | – |
| Sex mismatched | 304 (50) | 0.73 (0.58-0.92) | .0072 |
| CD3 chimerism status | |||
| Full donor chimerism | 329 (58) | Reference | – |
| Mixed chimerism | 240 (42) | 1.44 (1.13-1.84) | .004 |
| Acute GVHD | |||
| Absent | 528 (86) | Reference | – |
| Present | 84 (14) | 0.64 (0.43-0.96) | .030 |
| Chronic GVHD | |||
| Absent | 464 (76) | Reference | – |
| Present | 148 (24) | 0.61 (0.46-0.81) | .0007 |
| Variable . | n (%) . | Hazard ratio (95% CI) . | P . |
|---|---|---|---|
| OS | |||
| Age, y | |||
| <65 | 454 (74) | Reference | – |
| ≥65 | 158 (26) | 1.53 (1.19-1.96) | .0008 |
| Comorbidity index | |||
| HCT-CI < 3 | 403 (66) | Reference | – |
| HCT-CI ≥ 3 | 209 (34) | 1.19 (0.94-1.51) | .154 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 1.12 (0.89-1.43) | .338 |
| HLA-MMUD | 89 (15) | 1.20 (0.87-1.66) | .273 |
| DRI | |||
| Low | 140 (23) | Reference | – |
| Intermediate | 289 (47) | 1.46 (1.08-1.98) | .015 |
| High or very high | 183 (30) | 2.66 (1.94-3.66) | <.0001 |
| NRM | |||
| Age, y | |||
| <65 | 454 (74) | Reference | – |
| ≥65 | 158 (26) | 1.32 (0.80-2.16) | .270 |
| Comorbidity index | |||
| HCT-CI < 3 | 403 (66) | Reference | – |
| HCT-CI ≥ 3 | 209 (34) | 1.53 (0.99-2.35) | .056 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 1.78 (1.09-2.91) | .022 |
| HLA-MMUD | 89 (15) | 3.23 (1.88-5.57) | .0002 |
| Relapse | |||
| DRI | |||
| Low | 140 (23) | Reference | – |
| Intermediate | 289 (47) | 1.27 (0.95-1.69) | .11 |
| High or very high | 183 (30) | 1.77 (1.28-2.44) | .005 |
| Donor | |||
| HLA-MRD | 271 (44) | Reference | – |
| HLA-MUD | 250 (41) | 0.96 (0.75-1.23) | .75 |
| HLA-MMUD | 89 (15) | 0.68 (0.44-1.06) | .085 |
| Donor and recipient sex matching | |||
| Sex matched | 308 (50) | Reference | – |
| Sex mismatched | 304 (50) | 0.73 (0.58-0.92) | .0072 |
| CD3 chimerism status | |||
| Full donor chimerism | 329 (58) | Reference | – |
| Mixed chimerism | 240 (42) | 1.44 (1.13-1.84) | .004 |
| Acute GVHD | |||
| Absent | 528 (86) | Reference | – |
| Present | 84 (14) | 0.64 (0.43-0.96) | .030 |
| Chronic GVHD | |||
| Absent | 464 (76) | Reference | – |
| Present | 148 (24) | 0.61 (0.46-0.81) | .0007 |
Significant P values are shown in bold.