Basic characteristics and blood tests according to MPN status
| . | Mutation positive . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . | |
|---|---|---|---|---|---|---|
| Non-MPN (A) . | MPN (B) . | |||||
| Number | 629 | 16 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 285/344 (45/55) | 7/9 (44/56) | .9 | 10 566/8747 (55/45) | <.0001 | .4 |
| Age, y | 60 (0.51) | 68 (2.9) | .02 | 56 (0.098) | <.0001 | .001 |
| Allele burden, % | 1.6 (0.20) | 35 (8.1) | <.0001 | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.053) | 13.5 (0.37) | .03 | 14.0 (0.0089) | .02 | .03 |
| Hematocrit | 0.43 (0.0014) | 0.44 (0.013) | .2 | 0.43 (0.00024) | .005 | .06 |
| Leukocytes, ×109/L | 7.6 (0.078) | 11 (2.0) | .001 | 7.3 (0.014) | <.0001 | <.0001 |
| Neutrophils, ×109/L | 4.4 (0.057) | 6.3 (1.7) | .05 | 4.1 (0.0096) | <.0001 | .006 |
| Thrombocytes, ×109/L | 281 (4.0) | 370 (27) | <.0001 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 155 (4.7) | 54 (21) | <.0001 | 158 (1.2) | .008 | <.0001 |
| hsCRP, mg/L | 2.2 (0.12) | 4.4 (1.1) | .02 | 2.8 (0.039) | <.0001 | .06 |
| Cholesterol, mmol/L | 5.4 (0.042) | 4.4 (0.23) | <.0001 | 5.5 (0.0076) | 0.04 | <.0001 |
| Alkaline phosphatase, U/L | 68 (0.75) | 100 (12) | <.0001 | 68 (0.14) | .7 | <.0001 |
| eGFR, mL/min/1.73 m2 | 81 (0.66) | 71 (4.4) | .02 | 82 (0.12) | .08 | .006 |
| . | Mutation positive . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . | |
|---|---|---|---|---|---|---|
| Non-MPN (A) . | MPN (B) . | |||||
| Number | 629 | 16 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 285/344 (45/55) | 7/9 (44/56) | .9 | 10 566/8747 (55/45) | <.0001 | .4 |
| Age, y | 60 (0.51) | 68 (2.9) | .02 | 56 (0.098) | <.0001 | .001 |
| Allele burden, % | 1.6 (0.20) | 35 (8.1) | <.0001 | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.053) | 13.5 (0.37) | .03 | 14.0 (0.0089) | .02 | .03 |
| Hematocrit | 0.43 (0.0014) | 0.44 (0.013) | .2 | 0.43 (0.00024) | .005 | .06 |
| Leukocytes, ×109/L | 7.6 (0.078) | 11 (2.0) | .001 | 7.3 (0.014) | <.0001 | <.0001 |
| Neutrophils, ×109/L | 4.4 (0.057) | 6.3 (1.7) | .05 | 4.1 (0.0096) | <.0001 | .006 |
| Thrombocytes, ×109/L | 281 (4.0) | 370 (27) | <.0001 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 155 (4.7) | 54 (21) | <.0001 | 158 (1.2) | .008 | <.0001 |
| hsCRP, mg/L | 2.2 (0.12) | 4.4 (1.1) | .02 | 2.8 (0.039) | <.0001 | .06 |
| Cholesterol, mmol/L | 5.4 (0.042) | 4.4 (0.23) | <.0001 | 5.5 (0.0076) | 0.04 | <.0001 |
| Alkaline phosphatase, U/L | 68 (0.75) | 100 (12) | <.0001 | 68 (0.14) | .7 | <.0001 |
| eGFR, mL/min/1.73 m2 | 81 (0.66) | 71 (4.4) | .02 | 82 (0.12) | .08 | .006 |
Data are shown as raw mean (SE) for continuous variables. P values in bold are <.05