Basic characteristics and blood tests according to JAK2 V617F allele burden
| . | JAK2 V617F . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . | |
|---|---|---|---|---|---|---|
| <1% (A) . | ≥1% (B) . | |||||
| Number | 508 | 105 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 233/275 (46/54) | 48/57 (46/54) | 1.0 | 10 566/8747 (55/45) | <.0001 | .1 |
| Age, y | 60 (0.58) | 63 (1.2) | .02 | 56 (0.098) | <.0001 | <.0001 |
| Allele burden, % | 0.18 (0.0090) | 12 (1.7) | — | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.058) | 14.3 (0.14) | .08 | 14.0 (0.0089) | .3 | .01 |
| Hematocrit | 0.43 (0.0016) | 0.44 (0.0041) | .001 | 0.43 (0.00024) | .2 | <.0001 |
| Leukocytes, ×109/L | 7.5 (0.081) | 8.7 (0.38) | <.0001 | 7.3 (0.014) | .001 | <.0001 |
| Neutrophils, ×109/L | 4.3 (0.061) | 5.0 (0.26) | <.0001 | 4.1 (0.0096) | .002 | <.0001 |
| Thrombocytes, ×109/L | 264 (2.7) | 361 (15) | <.0001 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 151 (5.2) | 145 (10) | .2 | 158 (1.2) | .002 | .004 |
| hsCRP, mg/L | 2.2 (0.12) | 2.8 (0.38) | .4 | 2.8 (0.039) | .001 | .6 |
| Cholesterol, mmol/L | 5.4 (0.046) | 5.1 (0.11) | .001 | 5.5 (0.0076) | .3 | <.0001 |
| Alkaline phosphatase, U/L | 69 (0.81) | 72 (2.9) | .8 | 68 (0.14) | .7 | .6 |
| eGFR, mL/min/1.73 m2 | 81 (0.73) | 81 (1.7) | .9 | 82 (0.12) | .1 | .4 |
| . | JAK2 V617F . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . | |
|---|---|---|---|---|---|---|
| <1% (A) . | ≥1% (B) . | |||||
| Number | 508 | 105 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 233/275 (46/54) | 48/57 (46/54) | 1.0 | 10 566/8747 (55/45) | <.0001 | .1 |
| Age, y | 60 (0.58) | 63 (1.2) | .02 | 56 (0.098) | <.0001 | <.0001 |
| Allele burden, % | 0.18 (0.0090) | 12 (1.7) | — | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.058) | 14.3 (0.14) | .08 | 14.0 (0.0089) | .3 | .01 |
| Hematocrit | 0.43 (0.0016) | 0.44 (0.0041) | .001 | 0.43 (0.00024) | .2 | <.0001 |
| Leukocytes, ×109/L | 7.5 (0.081) | 8.7 (0.38) | <.0001 | 7.3 (0.014) | .001 | <.0001 |
| Neutrophils, ×109/L | 4.3 (0.061) | 5.0 (0.26) | <.0001 | 4.1 (0.0096) | .002 | <.0001 |
| Thrombocytes, ×109/L | 264 (2.7) | 361 (15) | <.0001 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 151 (5.2) | 145 (10) | .2 | 158 (1.2) | .002 | .004 |
| hsCRP, mg/L | 2.2 (0.12) | 2.8 (0.38) | .4 | 2.8 (0.039) | .001 | .6 |
| Cholesterol, mmol/L | 5.4 (0.046) | 5.1 (0.11) | .001 | 5.5 (0.0076) | .3 | <.0001 |
| Alkaline phosphatase, U/L | 69 (0.81) | 72 (2.9) | .8 | 68 (0.14) | .7 | .6 |
| eGFR, mL/min/1.73 m2 | 81 (0.73) | 81 (1.7) | .9 | 82 (0.12) | .1 | .4 |
Data are shown as raw mean (SE) for continuous variables. P values in bold are <.05