NPM1 c.863_864 4 bp insertion/duplication mutations, according to their number of N-nucleotides
| No. N-nucleotides added . | No. adult mutations observed (n = 2257) . | Adult: % observed . | Expected in population of n = 82 . | No. of pediatric mutations observed (n = 82) . | Pediatric: ratio predicted/observed . | P . |
|---|---|---|---|---|---|---|
| 1 | 1750 | 77.5 | 63.6 | 43 | 0.7 | <.001 |
| 2 | 160 | 7.1 | 5.8 | 8 | 1.4 | .379 |
| 3 | 254 | 11.3 | 9.2 | 22 | 2.4 | <.001 |
| 4 | 71 | 3.1 | 2.6 | 7 | 2.7 | .018 |
| 5 | 22 | 1.0 | 0.8 | 2 | 2.5 | .205 |
| 3-5 | 347 | 15.4 | 12.6 | 31 | 2.5 | <.001 |
| No. N-nucleotides added . | No. adult mutations observed (n = 2257) . | Adult: % observed . | Expected in population of n = 82 . | No. of pediatric mutations observed (n = 82) . | Pediatric: ratio predicted/observed . | P . |
|---|---|---|---|---|---|---|
| 1 | 1750 | 77.5 | 63.6 | 43 | 0.7 | <.001 |
| 2 | 160 | 7.1 | 5.8 | 8 | 1.4 | .379 |
| 3 | 254 | 11.3 | 9.2 | 22 | 2.4 | <.001 |
| 4 | 71 | 3.1 | 2.6 | 7 | 2.7 | .018 |
| 5 | 22 | 1.0 | 0.8 | 2 | 2.5 | .205 |
| 3-5 | 347 | 15.4 | 12.6 | 31 | 2.5 | <.001 |
A Bonferroni correction of 6 was applied, hence P < .0083 was considered significant.