Table 1. Dabigatran laboratory... | American Society of Hematology

Table 1.

Dabigatran laboratory evaluation

Tests/assays	Suggested indications and interpretations
PT	On therapy—usually unaffected
PT	Above on therapy—will be prolonged
aPTT	Perform Stat
	On therapy—often prolonged
	Above on therapy—always prolonged
	Normal—does not rule out clinically relevant* drug level
Thrombin time	Should perform Stat
	On therapy—always prolonged.
	Exquisitely sensitive to very low levels of drug
	Normal—probably rules out clinically relevant* drug level
(1) Dilute thrombin time, (2) ecarin clotting time, and (3) ecarin chromogenic assay	Often not offered Stat
	Measure accurate dabigatran concentrations in nanograms per milliliter
	May be useful for compliance or failed therapy
	Scheduled major or critical surgery

Tests/assays	Suggested indications and interpretations
PT	On therapy—usually unaffected
PT	Above on therapy—will be prolonged
aPTT	Perform Stat
	On therapy—often prolonged
	Above on therapy—always prolonged
	Normal—does not rule out clinically relevant* drug level
Thrombin time	Should perform Stat
	On therapy—always prolonged.
	Exquisitely sensitive to very low levels of drug
	Normal—probably rules out clinically relevant* drug level
(1) Dilute thrombin time, (2) ecarin clotting time, and (3) ecarin chromogenic assay	Often not offered Stat
	Measure accurate dabigatran concentrations in nanograms per milliliter
	May be useful for compliance or failed therapy
	Scheduled major or critical surgery

Level is <75 ng/mL for bleeding and <50 to 30 ng/mL for urgent surgery.⁷