Different functions of NFAT transcription factors in innate cells
| Cell type . | NFAT . | Function . | Reference(s) . |
|---|---|---|---|
| DCs | NFAT1 NFAT2 | Regulation of the DC life cycle/apoptosis of terminally differentiated DCs in response to LPS | 8 |
| Regulation of IL-2, IL-10, and IL-12 expression | 1,4,26,35 | ||
| Activation of NK cells | 4,5 | ||
| Macrophages | NFAT1, | Regulation of IL-6, IL-10, and IL-12 and TNF-α expression | 5,26,29,65 |
| NFAT2, NFAT4, NFAT5 | Regulation of multiple TLR-induced genes (eg, Nos2, inducible nitric oxide synthase [iNOS]) | 60 | |
| Mast cells | NFAT1, | Regulation of mast cell activation during hypoxia | 74 |
| NFAT2 | Enhanced mast cell survival after FcϵRI activation resulting from regulation of A1 expression | 76,77 | |
| Regulation of IL-13 and TNF expression | 110 | ||
| Neutrophils | NFAT2, NFAT4 | Regulation of IgE-mediated expression of cyclo-oxygenase and release of prostaglandin | 82 |
| Resistance to C albicans infection; genes involved include IL-10, Cox2, Egr1, and Egr2 | 3 | ||
| Eosinophils | NFAT1, | Degranulation, cytokine release, apoptosis | 84,88 |
| NFAT2 | |||
| Basophils | NFAT2 | Regulation of IL-4 production | 83,91 |
| Megakaryocytes | NFAT2, | Role in megakaryocyte differentiation | 10 |
| NFAT3 | Mediates CD154 expression | 111 | |
| Osteoclasts | NFAT2 | Master regulator of osteoclastogenesis | 69,112 |
| NK cells | NFAT1, | Inducible NFAT expression | 92 |
| NFAT2 | Mediates CD16-induced activation of cytokine genes | 94,95 | |
| Role in cytotoxicity and cell proliferation | 94,96 |
| Cell type . | NFAT . | Function . | Reference(s) . |
|---|---|---|---|
| DCs | NFAT1 NFAT2 | Regulation of the DC life cycle/apoptosis of terminally differentiated DCs in response to LPS | 8 |
| Regulation of IL-2, IL-10, and IL-12 expression | 1,4,26,35 | ||
| Activation of NK cells | 4,5 | ||
| Macrophages | NFAT1, | Regulation of IL-6, IL-10, and IL-12 and TNF-α expression | 5,26,29,65 |
| NFAT2, NFAT4, NFAT5 | Regulation of multiple TLR-induced genes (eg, Nos2, inducible nitric oxide synthase [iNOS]) | 60 | |
| Mast cells | NFAT1, | Regulation of mast cell activation during hypoxia | 74 |
| NFAT2 | Enhanced mast cell survival after FcϵRI activation resulting from regulation of A1 expression | 76,77 | |
| Regulation of IL-13 and TNF expression | 110 | ||
| Neutrophils | NFAT2, NFAT4 | Regulation of IgE-mediated expression of cyclo-oxygenase and release of prostaglandin | 82 |
| Resistance to C albicans infection; genes involved include IL-10, Cox2, Egr1, and Egr2 | 3 | ||
| Eosinophils | NFAT1, | Degranulation, cytokine release, apoptosis | 84,88 |
| NFAT2 | |||
| Basophils | NFAT2 | Regulation of IL-4 production | 83,91 |
| Megakaryocytes | NFAT2, | Role in megakaryocyte differentiation | 10 |
| NFAT3 | Mediates CD154 expression | 111 | |
| Osteoclasts | NFAT2 | Master regulator of osteoclastogenesis | 69,112 |
| NK cells | NFAT1, | Inducible NFAT expression | 92 |
| NFAT2 | Mediates CD16-induced activation of cytokine genes | 94,95 | |
| Role in cytotoxicity and cell proliferation | 94,96 |