Table 9

Multivariate analysis of TNF-1031 genotype mismatch and CC genotype as a risk factors* for acute GVHD grade 4 in the overall (HLA matched and mismatched) cohort

VariableUnivariate
Multivariate
OR (95% CI)POR (95% CI)P
Recipient age 0.978 (0.95-1.01) .109 0.975 (0.94-1.01) .112 
Donor age 1.038 (1.00-1.08) .044 1.033 (0.99-1.07) .105 
Female to male transplant 0.610 (0.27-1.38) .235 0.582 (0.24-1.42) .236 
Diagnosis ANLL vs ALL 1.001 (0.57-1.76) .996 1.148 (0.60-2.18) .673 
Total body irradiation 0.909 (0.40-2.07) .819 0.992 (0.39-2.51) .987 
Antithymoglobulin 3.562 (0.99-12.73) .051 2.246 (0.45-11.15) .322 
Cyclosporine vs tacrolimus 1.336 (0.75-2.37) .321 1.516 (0.80-2.86) .198 
Relapse 0.115 (0.03-0.48) .003 0.154 (0.04-0.65) .011 
HLA match 0.465 (0.24-0.92) .027 0.765 (0.35-1.67) .502 
Genotype CC 4.336 (1.7-11.1) .002 3.888 (1.39-10.90) .010 
Genotype mismatch 2.905 (1.65-5.1) .00023 2.307 (1.18-4.52) .015 
VariableUnivariate
Multivariate
OR (95% CI)POR (95% CI)P
Recipient age 0.978 (0.95-1.01) .109 0.975 (0.94-1.01) .112 
Donor age 1.038 (1.00-1.08) .044 1.033 (0.99-1.07) .105 
Female to male transplant 0.610 (0.27-1.38) .235 0.582 (0.24-1.42) .236 
Diagnosis ANLL vs ALL 1.001 (0.57-1.76) .996 1.148 (0.60-2.18) .673 
Total body irradiation 0.909 (0.40-2.07) .819 0.992 (0.39-2.51) .987 
Antithymoglobulin 3.562 (0.99-12.73) .051 2.246 (0.45-11.15) .322 
Cyclosporine vs tacrolimus 1.336 (0.75-2.37) .321 1.516 (0.80-2.86) .198 
Relapse 0.115 (0.03-0.48) .003 0.154 (0.04-0.65) .011 
HLA match 0.465 (0.24-0.92) .027 0.765 (0.35-1.67) .502 
Genotype CC 4.336 (1.7-11.1) .002 3.888 (1.39-10.90) .010 
Genotype mismatch 2.905 (1.65-5.1) .00023 2.307 (1.18-4.52) .015 
*

Both are independent risk factors, with competing effects from HLA matching and relapse.