SNP markers showing significant association in recipient screening and cohorts
| Marker . | Genotype . | Cohort . | Outcome . | P . | Total . | Cases, all . | Controls, all . | Cases positive . | Cases negative . | Controls positive . | Controls negative . | OR . | OR (95% CI) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TNF-1031 | Mismatch | Screening | aGVHD4 | .022 | 448 | 28 | 420 | 12 | 16 | 96 | 324 | 2.53 | 1.16-5.53 |
| rs1799964, recipients (all) | Mismatch | Confirmation | aGVHD4 | .0053 | 460 | 24 | 436 | 12 | 12 | 99 | 337 | 3.40 | 1.48-7.81 |
| IL2-330 | GT | Screening | cGVHD | .039 | 160 | 72 | 88 | 39 | 33 | 33 | 55 | 1.97 | 1.05-3.71 |
| rs2069762, recipients (HLA matched) | GT | Confirmation | cGVHD | .00041 | 166 | 75 | 92 | 40 | 35 | 23 | 68 | 3.24 | 1.70-6.20 |
| CTLA4-CT60 | GG | Random 1 | aGVHD | .022 | 159 | 58 | 101 | 20 | 38 | 54 | 47 | 0.46 | 0.27-0.78 |
| rs3087243, donors (HLA matched) | GG | Random 2 | aGVHD | .045 | 166 | 53 | 11 | 22 | 31 | 67 | 46 | 0.49 | 0.29-0.83 |
| Marker . | Genotype . | Cohort . | Outcome . | P . | Total . | Cases, all . | Controls, all . | Cases positive . | Cases negative . | Controls positive . | Controls negative . | OR . | OR (95% CI) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TNF-1031 | Mismatch | Screening | aGVHD4 | .022 | 448 | 28 | 420 | 12 | 16 | 96 | 324 | 2.53 | 1.16-5.53 |
| rs1799964, recipients (all) | Mismatch | Confirmation | aGVHD4 | .0053 | 460 | 24 | 436 | 12 | 12 | 99 | 337 | 3.40 | 1.48-7.81 |
| IL2-330 | GT | Screening | cGVHD | .039 | 160 | 72 | 88 | 39 | 33 | 33 | 55 | 1.97 | 1.05-3.71 |
| rs2069762, recipients (HLA matched) | GT | Confirmation | cGVHD | .00041 | 166 | 75 | 92 | 40 | 35 | 23 | 68 | 3.24 | 1.70-6.20 |
| CTLA4-CT60 | GG | Random 1 | aGVHD | .022 | 159 | 58 | 101 | 20 | 38 | 54 | 47 | 0.46 | 0.27-0.78 |
| rs3087243, donors (HLA matched) | GG | Random 2 | aGVHD | .045 | 166 | 53 | 11 | 22 | 31 | 67 | 46 | 0.49 | 0.29-0.83 |