Results of SNP genotyping on HLA-matched donor samples
| Gene . | Marker . | Discovery cohort (genotype and association) . | Confirmatory cohort (genotype and association) . |
|---|---|---|---|
| CTLA4 | rs231775 | GG aGVHD* (P = .026, OR = 2.02,* CI = 1.09-3.75) | NS |
| CTLA4 | rs3087243 | GG aGVHD (P = .021, OR = 1.97, CI = 1.11-3.50) | NS |
| CTLA4 | Haplotype | CAA aGVHD (P = .012, OR = 0.55, CI = 0.35-0.87) | NS |
| CGG aGVHD* (P = .00097,* OR = 2.06,* CI = 1.22-5.94) | NS | ||
| IFNg | rs2069705 | CC ext cGVHD* (P = .036, OR = 0.42,* CI = 0.20-0.93) | NS |
| CT ext cGVHD* (P = .017, OR = 2.69,* CI = 1.22-5.94) | NS | ||
| IL10 | rs1800896 | AA aGVHD* (P = .038, OR = 0.21,* CI = 0.04-0.96) | NS |
| IL10 | Haplotype | CCG aGVHD* (P = .027, OR = 4.70, CI = 1.08-20.54) | NS |
| MTHFR | rs1801133 | TT aGVHD (P = .0016, OR = 12.13,* CI = 2.73-53.90) | NT |
| NOD2 | rs17313265 | CT relapse* (P = .013, OR = 2.68,* CI = 1.02-7.09) | NS |
| TNF | rs1799724 | CC survival (P = .006) protective | NT |
| Gene . | Marker . | Discovery cohort (genotype and association) . | Confirmatory cohort (genotype and association) . |
|---|---|---|---|
| CTLA4 | rs231775 | GG aGVHD* (P = .026, OR = 2.02,* CI = 1.09-3.75) | NS |
| CTLA4 | rs3087243 | GG aGVHD (P = .021, OR = 1.97, CI = 1.11-3.50) | NS |
| CTLA4 | Haplotype | CAA aGVHD (P = .012, OR = 0.55, CI = 0.35-0.87) | NS |
| CGG aGVHD* (P = .00097,* OR = 2.06,* CI = 1.22-5.94) | NS | ||
| IFNg | rs2069705 | CC ext cGVHD* (P = .036, OR = 0.42,* CI = 0.20-0.93) | NS |
| CT ext cGVHD* (P = .017, OR = 2.69,* CI = 1.22-5.94) | NS | ||
| IL10 | rs1800896 | AA aGVHD* (P = .038, OR = 0.21,* CI = 0.04-0.96) | NS |
| IL10 | Haplotype | CCG aGVHD* (P = .027, OR = 4.70, CI = 1.08-20.54) | NS |
| MTHFR | rs1801133 | TT aGVHD (P = .0016, OR = 12.13,* CI = 2.73-53.90) | NT |
| NOD2 | rs17313265 | CT relapse* (P = .013, OR = 2.68,* CI = 1.02-7.09) | NS |
| TNF | rs1799724 | CC survival (P = .006) protective | NT |
NS indicates not significant; and NT, not tested. Explanation of other abbreviations found in Table 2.
Withstanding Bonferroni multiple testing corrections or have OR ≤ 0.5 or ≥ 2.