Risk of GVHD and relapse
| Reference . | n . | Diseases . | Conditioning . | GVHD ppx . | Relapse, % . | II-IV Acute GVHD, % . | Chronic GVHD, % . |
|---|---|---|---|---|---|---|---|
| UCB | |||||||
| Eapen13 | 165 | AML, ALL | Various myeloablative | Various | 30 | 30 | 24 |
| Brunstein15 | 128 | AML, ALL, CML, MDS | Flu/Cy/TBI-ablative | CNI + MMF | 15 | 60 | 26 |
| Chen20 | 64 | Various | Flu/Mel/ATG-RIC | Various | 43 | 14 | 22 |
| Haplo | |||||||
| Aversa45 | 104 | AML, ALL | TBI, TT, Flu, ATG-myeloablative | TCD | 25 | 8 | 7 |
| Rizzieri51 | 49 | Various | Flu/Cy/alemtuzumab-RIC | CsA ± MMF | NA | 16 | 14 |
| Luznik52 | 68 | Various | Flu/Cy/TBI-RIC | Cy/Tacro/MMF | 58 | 34 | 13 |
| MMUD | |||||||
| Pidala61 | 45 | Various | Various | ATG/Tacro/MTX | 33 | 64 | 35 |
| Kroger93 | 158 | Various | Various | F-ATG/CsA/MTX | 27 | 41 | 41 |
| Mead63 | 50 | Various | Flu/Mel/alemtuzumab | CsA | NA | 22 | 39 |
| Reference . | n . | Diseases . | Conditioning . | GVHD ppx . | Relapse, % . | II-IV Acute GVHD, % . | Chronic GVHD, % . |
|---|---|---|---|---|---|---|---|
| UCB | |||||||
| Eapen13 | 165 | AML, ALL | Various myeloablative | Various | 30 | 30 | 24 |
| Brunstein15 | 128 | AML, ALL, CML, MDS | Flu/Cy/TBI-ablative | CNI + MMF | 15 | 60 | 26 |
| Chen20 | 64 | Various | Flu/Mel/ATG-RIC | Various | 43 | 14 | 22 |
| Haplo | |||||||
| Aversa45 | 104 | AML, ALL | TBI, TT, Flu, ATG-myeloablative | TCD | 25 | 8 | 7 |
| Rizzieri51 | 49 | Various | Flu/Cy/alemtuzumab-RIC | CsA ± MMF | NA | 16 | 14 |
| Luznik52 | 68 | Various | Flu/Cy/TBI-RIC | Cy/Tacro/MMF | 58 | 34 | 13 |
| MMUD | |||||||
| Pidala61 | 45 | Various | Various | ATG/Tacro/MTX | 33 | 64 | 35 |
| Kroger93 | 158 | Various | Various | F-ATG/CsA/MTX | 27 | 41 | 41 |
| Mead63 | 50 | Various | Flu/Mel/alemtuzumab | CsA | NA | 22 | 39 |
ALL indicates acute lymphoblastic leukemia; CML, chronic myeloid leukemia; MDS, myelodysplastic syndrome; Flu, fludarabine; Cy, cyclophosphamide; Mel, melphalan; TT, thiotepa; CNI, calcineurin inhibitor; MMF, mycophenolate mofetil; TCD, T-cell depletion; CsA, cyclosporine A; Tacro, tacrolimus; MTX, methotrexate; F-ATG, Fresenius ATG; and NA, not available.