Advantages and disadvantages of alternative donor sources
| . | UCB . | Haploidentical-related family member . | One locus mismatched unrelated donor . |
|---|---|---|---|
| Donor availability | Difficulty to find high-quality units for minorities | Most patients have parent or child as donor | May be lengthy/difficult to find donors, especially for minorities |
| Cost | US $20 000-$40 000 per cord unit | Low donor acquisition costs | US $20 000-25 000 |
| Availability of donor lymphocytes | No | Yes, readily available | Available, but may be lengthy wait |
| GVHD | Low risk | May be severe, especially with no T-cell depletion | May be very severe |
| Infection | High risk, especially viral | High risk | Moderate risk |
| Product quality | High variability | Low variability | Low variability |
| Relapse risk | Moderate | High, especially with some forms of T-cell depletion | Moderate |
| . | UCB . | Haploidentical-related family member . | One locus mismatched unrelated donor . |
|---|---|---|---|
| Donor availability | Difficulty to find high-quality units for minorities | Most patients have parent or child as donor | May be lengthy/difficult to find donors, especially for minorities |
| Cost | US $20 000-$40 000 per cord unit | Low donor acquisition costs | US $20 000-25 000 |
| Availability of donor lymphocytes | No | Yes, readily available | Available, but may be lengthy wait |
| GVHD | Low risk | May be severe, especially with no T-cell depletion | May be very severe |
| Infection | High risk, especially viral | High risk | Moderate risk |
| Product quality | High variability | Low variability | Low variability |
| Relapse risk | Moderate | High, especially with some forms of T-cell depletion | Moderate |