Laboratory abnormalities reported by ≥ 20% of patients on therapy
| Laboratory abnormality . | At baseline . | On therapy . | ||
|---|---|---|---|---|
| All grades . | Grade 3/4 . | All grades . | Grade 3/4 . | |
| Anemia | 66 (56) | 1 (1) | 99 (84) | 10 (8) |
| Thrombocytopenia | 20 (17) | 1 (1) | 69 (58) | 30 (25) |
| Elevated ALT | 12 (10) | 0 | 58 (49) | 8 (7) |
| Neutropenia | 23 (19) | 4 (3) | 54 (46) | 23 (19) |
| Elevated creatinine | 13 (11) | 0 | 50 (42) | 1 (1) |
| Elevated AST | 15 (13) | 0 | 48 (41) | 4 (3) |
| Hypocalcemia | 8 (7) | 1 (1) | 44 (37) | 6 (5) |
| Elevated alkaline phosphatase | 12 (10) | 0 | 41 (35) | 0 |
| Hypophosphatemia | 8 (7) | 0 | 37 (31) | 3 (2) |
| Hyperglycemia | 15 (13) | 0 | 36 (31) | 1 (1) |
| Low bicarbonate | 4 (3) | 0 | 36 (31) | 0 |
| Hypermagnesemia | 11 (9) | 9 (8) | 34 (29) | 14 (12) |
| Increased PTT | 16 (14) | 0 | 30 (25) | 1 (1) |
| Elevated lipase | 7 (6) | 0 | 28 (24) | 8 (7) |
| Hyperkalemia | 3 (3) | 1 (1) | 27 (23) | 0 |
| Laboratory abnormality . | At baseline . | On therapy . | ||
|---|---|---|---|---|
| All grades . | Grade 3/4 . | All grades . | Grade 3/4 . | |
| Anemia | 66 (56) | 1 (1) | 99 (84) | 10 (8) |
| Thrombocytopenia | 20 (17) | 1 (1) | 69 (58) | 30 (25) |
| Elevated ALT | 12 (10) | 0 | 58 (49) | 8 (7) |
| Neutropenia | 23 (19) | 4 (3) | 54 (46) | 23 (19) |
| Elevated creatinine | 13 (11) | 0 | 50 (42) | 1 (1) |
| Elevated AST | 15 (13) | 0 | 48 (41) | 4 (3) |
| Hypocalcemia | 8 (7) | 1 (1) | 44 (37) | 6 (5) |
| Elevated alkaline phosphatase | 12 (10) | 0 | 41 (35) | 0 |
| Hypophosphatemia | 8 (7) | 0 | 37 (31) | 3 (2) |
| Hyperglycemia | 15 (13) | 0 | 36 (31) | 1 (1) |
| Low bicarbonate | 4 (3) | 0 | 36 (31) | 0 |
| Hypermagnesemia | 11 (9) | 9 (8) | 34 (29) | 14 (12) |
| Increased PTT | 16 (14) | 0 | 30 (25) | 1 (1) |
| Elevated lipase | 7 (6) | 0 | 28 (24) | 8 (7) |
| Hyperkalemia | 3 (3) | 1 (1) | 27 (23) | 0 |
Data are n (%).
PTT indicates partial thromboplastin time.