Table 5 Multivariate analysis (Cox... | American Society of Hematology

Table 5

Multivariate analysis (Cox regression) for relapse-free and overall survival

Variable	Relapse-free survival				Overall survival
	HR	95% CI		P	HR	95% CI		P
	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	1.150	0.803	1.648	.446	2.531	1.790	3.580	< .001†
WBC‡	1.649	1.120	2.428	.011†	1.970	1.358	2.857	< .001†
Karyotype§	2.577	1.433	4.633	.002†	3.078	1.849	5.123	< .001†
NPM1/FLT3-ITD¶	0.268	0.124	0.581	.001†	0.261	0.121	0.564	.001†
CEBPA#	0.629	0.362	1.093	.100	0.423	0.211	0.847	.015†
IDH2**	0.775	0.420	1.430	.415	0.573	0.296	1.110	.099
WT1	2.823	1.680	4.743	<.001†	2.576	1.490	4.454	.001†
AML1/RUNX1	1.448	0.718	2.918	.301	1.963	1.129	3.414	.017†
ASXL1	0.739	0.293	1.863	.521	1.439	0.798	2.597	.227
TET2	1.125	0.625	2.026	.694	1.033	0.601	1.777	.906
DNMT3A	2.898	1.673	5.022	<.001†	2.218	1.333	3.692	.002†

Variable	Relapse-free survival				Overall survival
	HR	95% CI		P	HR	95% CI		P
	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	1.150	0.803	1.648	.446	2.531	1.790	3.580	< .001†
WBC‡	1.649	1.120	2.428	.011†	1.970	1.358	2.857	< .001†
Karyotype§	2.577	1.433	4.633	.002†	3.078	1.849	5.123	< .001†
NPM1/FLT3-ITD¶	0.268	0.124	0.581	.001†	0.261	0.121	0.564	.001†
CEBPA#	0.629	0.362	1.093	.100	0.423	0.211	0.847	.015†
IDH2**	0.775	0.420	1.430	.415	0.573	0.296	1.110	.099
WT1	2.823	1.680	4.743	<.001†	2.576	1.490	4.454	.001†
AML1/RUNX1	1.448	0.718	2.918	.301	1.963	1.129	3.414	.017†
ASXL1	0.739	0.293	1.863	.521	1.439	0.798	2.597	.227
TET2	1.125	0.625	2.026	.694	1.033	0.601	1.777	.906
DNMT3A	2.898	1.673	5.022	<.001†	2.218	1.333	3.692	.002†

HR indicates hazard ratio; and 95% CI, 95% confidence interval.

Age > 50 relative to age ≤ 50 (the reference age).

Statistically significant (P < .05).

WBCs > 50 000/μL versus < 50 000/μL.

Unfavorable cytogenetics versus others.

NPM1^mut/FLT3-ITD^neg versus other subtypes.

CEBPA^{double-mutation} versus others.

IDH2 mutations included R140 and R172 mutations.