Table 3 Multivariate analysis for OS and... | American Society of Hematology

Table 3

Multivariate analysis for OS and PFS after R-CHOP21 in the training and validation DLBCL series

	Training series				Validation series
	HR	LCI	UCI	P	HR	LCI	UCI	P
OS
MLH1 rs1799977 AG/GG	3.14	1.67	5.91	< .001*	3.04	1.45	6.37	.003*
Bulky	2.56	1.34	4.89	.004*	1.57	0.74	3.33	.233
IPI	1.38	1.02	1.88	.037*	1.85	1.35	2.53	< .001*
RDI doxorubicin < 90%	1.19	0.58	2.43	.642	NA	NA	NA	NA
PFS
MLH1 rs1799977 AG/GG	1.96	1.17	3.28	.010*	1.98	1.12	3.50	.019*
Bulky	1.96	1.15	3.34	.012*	1.01	0.54	1.91	.954
IPI	1.41	1.12	1.77	.002*	1.86	1.45	2.38	< .001*

	Training series				Validation series
	HR	LCI	UCI	P	HR	LCI	UCI	P
OS
MLH1 rs1799977 AG/GG	3.14	1.67	5.91	< .001*	3.04	1.45	6.37	.003*
Bulky	2.56	1.34	4.89	.004*	1.57	0.74	3.33	.233
IPI	1.38	1.02	1.88	.037*	1.85	1.35	2.53	< .001*
RDI doxorubicin < 90%	1.19	0.58	2.43	.642	NA	NA	NA	NA
PFS
MLH1 rs1799977 AG/GG	1.96	1.17	3.28	.010*	1.98	1.12	3.50	.019*
Bulky	1.96	1.15	3.34	.012*	1.01	0.54	1.91	.954
IPI	1.41	1.12	1.77	.002*	1.86	1.45	2.38	< .001*

LCI indicates 95% lower confidence interval; UCI, 95% upper confidence interval; and NA, not applicable.

Significant value.