Extrahematologic toxicities (WHO grade > 2)
| Patient no. . | Induction treatment . | Postremission treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| Toxicity . | WHO grade . | Action taken . | Outcome . | Toxicity . | WHO grade . | Action taken . | Outcome . | |
| 1 | Peripheral nervous system | 3 | TD | Resolved | Peripheral nervous system | 3 | DD | Resolved |
| 2 | Peripheral nervous system | 3 | TD | Resolved | Peripheral nervous system | 3 | DD | Off protocol |
| 3 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 4 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 5 | None | NA | NA | NA | Cutaneous | 3 | DD | Off protocol |
| 6 | Nausea/Vomiting | 3 | TD | Resolved | Gastrointestinal | 3 | DD | Off protocol |
| 7 | None | NA | NA | NA | Cardiac | 3 | DD | Off protocol |
| 8 | Gastrointestinal | 4 | TD | Resolved | None | NA | NA | NA |
| 9 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 10 | Liver toxicity | 3 | TD | Resolved | None | NA | NA | NA |
| 11 | Edema | 3 | TD | Resolved | Cutaneous | 3 | DD | Off protocol |
| 12 | None | NA | NA | NA | Edema | 3 | TD | Resolved |
| 13 | Liver toxicity | 3 | TD | Resolved | None | NA | NA | NA |
| Patient no. . | Induction treatment . | Postremission treatment . | ||||||
|---|---|---|---|---|---|---|---|---|
| Toxicity . | WHO grade . | Action taken . | Outcome . | Toxicity . | WHO grade . | Action taken . | Outcome . | |
| 1 | Peripheral nervous system | 3 | TD | Resolved | Peripheral nervous system | 3 | DD | Resolved |
| 2 | Peripheral nervous system | 3 | TD | Resolved | Peripheral nervous system | 3 | DD | Off protocol |
| 3 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 4 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 5 | None | NA | NA | NA | Cutaneous | 3 | DD | Off protocol |
| 6 | Nausea/Vomiting | 3 | TD | Resolved | Gastrointestinal | 3 | DD | Off protocol |
| 7 | None | NA | NA | NA | Cardiac | 3 | DD | Off protocol |
| 8 | Gastrointestinal | 4 | TD | Resolved | None | NA | NA | NA |
| 9 | None | NA | NA | NA | Nausea/Vomiting | 3 | TD | Resolved |
| 10 | Liver toxicity | 3 | TD | Resolved | None | NA | NA | NA |
| 11 | Edema | 3 | TD | Resolved | Cutaneous | 3 | DD | Off protocol |
| 12 | None | NA | NA | NA | Edema | 3 | TD | Resolved |
| 13 | Liver toxicity | 3 | TD | Resolved | None | NA | NA | NA |
TD indicates temporary discontinuation; DD, definitive discontinuation; NA, not applicable.