Transcription factor-binding modules in SOD2-up-regulated gene promoters
| Transcription factor module . | Genes containing module . |
|---|---|
| STAT_FKHD | ADH4, ANKRD29, KLKB1, MYO3B |
| IKAROS_AP2 | ANKRD29, HK1, MYO3B, NCALD, PHF15, ZNF358 |
| LEFF_SMAD | ANKRD29, DDX55, MYO3B, NCALD, PHF15, PLAGL1 |
| STAT_ETS | ANKRD29, DDX55, HK1, PLAGL1 |
| CREB_CEBP | MYO3B, NCALD, PHF15 |
| AP1_ETS | HK1, KLKB1, MYO3B |
| CREB_EBOX | HK1, MYO3B, PHF15 |
| ETS_IRF | KLKB1, MYO3B, NCALD |
| NFkB_CREB | PHF15, PLAGL1 |
| LEFF_LEFF_LEFF | HK1, MMP7 |
| STAT_IRF | ANKRD29, NCALD |
| FKHD_CEBP | ADH4, NCALD |
| STAT_GRE | DDX55, KLKB1 |
| Transcription factor module . | Genes containing module . |
|---|---|
| STAT_FKHD | ADH4, ANKRD29, KLKB1, MYO3B |
| IKAROS_AP2 | ANKRD29, HK1, MYO3B, NCALD, PHF15, ZNF358 |
| LEFF_SMAD | ANKRD29, DDX55, MYO3B, NCALD, PHF15, PLAGL1 |
| STAT_ETS | ANKRD29, DDX55, HK1, PLAGL1 |
| CREB_CEBP | MYO3B, NCALD, PHF15 |
| AP1_ETS | HK1, KLKB1, MYO3B |
| CREB_EBOX | HK1, MYO3B, PHF15 |
| ETS_IRF | KLKB1, MYO3B, NCALD |
| NFkB_CREB | PHF15, PLAGL1 |
| LEFF_LEFF_LEFF | HK1, MMP7 |
| STAT_IRF | ANKRD29, NCALD |
| FKHD_CEBP | ADH4, NCALD |
| STAT_GRE | DDX55, KLKB1 |
Using Genomatix's Gene2Promoter software, we identifed the known and predicted promoters of 11 of 16 SOD2 up-regulated genes identified in Figure 5B. Using Genomatix's ModelInspector, we searched for promoter modules contained within the promtoers. This is a summarized list of the promoter modules identified. A detailed listing of the identified modules and the locations is provided in Table S3.