Table 4 Effect of donor availability on... | American Society of Hematology

Table 4

Effect of donor availability on outcome in AML in CR1

Outcome	Donor			No donor			P*	HR (95% CI)
Outcome	n	No. of events	Probability of outcome at 4 y ± SE, %	n	No. of events	Probability of outcome at 4 y ± SE, %	P*	HR (95% CI)
All patients	326			599
Survival		157	54 ± 3		326	46 ± 2	.09	0.85 (0.70–1.03)
DFS		171	48 ± 3		381	37 ± 2	< .001	0.71 (0.59–0.85)
Relapse		103	32 ± 3		354	59 ± 2	< .001	0.46 (0.37–0.57)
TRM		68	21 ± 2		27	4 ± 1	< .001	3.99 (2.55–6.25)
Good risk	32			73
Survival		9	84 ± 6		17	78 ± 5	.99	1.01 (0.45–2.27)
DFS		11	72 ± 8		28	64 ± 6	.40	0.74 (0.37–1.50)
Relapse		7	22 ± 7		24	32 ± 6	.17	0.57 (0.24–1.31)
TRM		4	6 ± 4		4	4 ± 2	.42	1.80 (0.44–7.31)
Intermediate risk	178			333
Survival		76	57 ± 4		172	48 ± 3	.23	0.85 (0.65–1.11)
DFS		82	53 ± 4		199	41 ± 3	.014	0.73 (0.56–0.94)
Relapse		50	28 ± 3		188	55 ± 3	< .001	0.47 (0.34–0.64)
TRM		32	19 ± 3		11	3 ± 1	< .001	5.13 (2.58–10.2)
Poor risk	116			193
Survival		72	40 ± 5		137	30 ± 4	.17	0.82 (0.62–1.09)
DFS		78	33 ± 4		154	17 ± 3	.003	0.67 (0.51–0.88)
Relapse		46	39 ± 5		142	77 ± 3	< .001	0.43 (0.31–0.60)
TRM		32	28 ± 4		12	6 ± 2	< .001	3.47 (1.78–6.77)
Age younger than 40 y	174			316
Survival		73	61 ± 4		164	49 ± 3	.015	0.71 (0.54–0.94)
DFS		81	55 ± 4		204	37 ± 3	< .001	0.59 (0.46–0.77)
Relapse		51	28 ± 3		187	58 ± 3	< .001	0.41 (0.30–0.56)
TRM		30	17 ± 3		17	5 ± 1	.002	2.6 (1.4–4.75)
Age older than 40 y	152			283
Survival		84	44 ± 4		162	42 ± 3	.84	0.97 (0.75–1.27)
DFS		90	39 ± 4		177	36 ± 3	.15	0.83 (0.64–1.07)
Relapse		52	35 ± 4		167	60 ± 3	< .001	0.51 (0.37–0.70)
TRM		38	25 ± 4		10	4 ± 1	< .001	6.07 (3.0–12.24)

Outcome	Donor			No donor			P*	HR (95% CI)
Outcome	n	No. of events	Probability of outcome at 4 y ± SE, %	n	No. of events	Probability of outcome at 4 y ± SE, %	P*	HR (95% CI)
All patients	326			599
Survival		157	54 ± 3		326	46 ± 2	.09	0.85 (0.70–1.03)
DFS		171	48 ± 3		381	37 ± 2	< .001	0.71 (0.59–0.85)
Relapse		103	32 ± 3		354	59 ± 2	< .001	0.46 (0.37–0.57)
TRM		68	21 ± 2		27	4 ± 1	< .001	3.99 (2.55–6.25)
Good risk	32			73
Survival		9	84 ± 6		17	78 ± 5	.99	1.01 (0.45–2.27)
DFS		11	72 ± 8		28	64 ± 6	.40	0.74 (0.37–1.50)
Relapse		7	22 ± 7		24	32 ± 6	.17	0.57 (0.24–1.31)
TRM		4	6 ± 4		4	4 ± 2	.42	1.80 (0.44–7.31)
Intermediate risk	178			333
Survival		76	57 ± 4		172	48 ± 3	.23	0.85 (0.65–1.11)
DFS		82	53 ± 4		199	41 ± 3	.014	0.73 (0.56–0.94)
Relapse		50	28 ± 3		188	55 ± 3	< .001	0.47 (0.34–0.64)
TRM		32	19 ± 3		11	3 ± 1	< .001	5.13 (2.58–10.2)
Poor risk	116			193
Survival		72	40 ± 5		137	30 ± 4	.17	0.82 (0.62–1.09)
DFS		78	33 ± 4		154	17 ± 3	.003	0.67 (0.51–0.88)
Relapse		46	39 ± 5		142	77 ± 3	< .001	0.43 (0.31–0.60)
TRM		32	28 ± 4		12	6 ± 2	< .001	3.47 (1.78–6.77)
Age younger than 40 y	174			316
Survival		73	61 ± 4		164	49 ± 3	.015	0.71 (0.54–0.94)
DFS		81	55 ± 4		204	37 ± 3	< .001	0.59 (0.46–0.77)
Relapse		51	28 ± 3		187	58 ± 3	< .001	0.41 (0.30–0.56)
TRM		30	17 ± 3		17	5 ± 1	.002	2.6 (1.4–4.75)
Age older than 40 y	152			283
Survival		84	44 ± 4		162	42 ± 3	.84	0.97 (0.75–1.27)
DFS		90	39 ± 4		177	36 ± 3	.15	0.83 (0.64–1.07)
Relapse		52	35 ± 4		167	60 ± 3	< .001	0.51 (0.37–0.70)
TRM		38	25 ± 4		10	4 ± 1	< .001	6.07 (3.0–12.24)

HR indicates hazard ratio for donor compared with no donor from multivariate Cox model adjusted for risk and age.

P from likelihood ratio test.