Decrease and redistribution of nonheme tissue iron stores in Tg+ mice
| Assay . | Tg−(N = 15) . | Tg+(N = 10) . | Tg−; Fe-def (N = 13) . | ANOVA . | |
|---|---|---|---|---|---|
| F test . | P . | ||||
| Liver Fe, μg/g | 92 ± 28 | 36 ± 9 | 65 ± 11 | 26.26 | < .001* |
| Spleen Fe, μg/g | 206 ± 62 | 184 ± 56 | 138 ± 21 | 6.64 | .004† |
| Serum Fe, μg/g | 177 ± 109 | 57 ± 60 | 246 ± 52 | 17.15 | < .001‡ |
| S:L ratio | 2.34 ± 0.71 | 5.56 ± 2.79 | 2.18 ± 0.45 | 19.43 | < .001§ |
| Assay . | Tg−(N = 15) . | Tg+(N = 10) . | Tg−; Fe-def (N = 13) . | ANOVA . | |
|---|---|---|---|---|---|
| F test . | P . | ||||
| Liver Fe, μg/g | 92 ± 28 | 36 ± 9 | 65 ± 11 | 26.26 | < .001* |
| Spleen Fe, μg/g | 206 ± 62 | 184 ± 56 | 138 ± 21 | 6.64 | .004† |
| Serum Fe, μg/g | 177 ± 109 | 57 ± 60 | 246 ± 52 | 17.15 | < .001‡ |
| S:L ratio | 2.34 ± 0.71 | 5.56 ± 2.79 | 2.18 ± 0.45 | 19.43 | < .001§ |
Liver Fe: Tg− vs Tg+ (P < .001); Tg− vs Tg−; Fe def (P = .002); Tg+ vs Tg−; Fe def (P = .003).
Spleen Fe: Tg− vs Tg+ (P = .91); Tg− vs Tg−; Fe def (P = .003); Tg+ vs Tg−; Fe def (P = .10).
Serum Fe: Tg− vs Tg+ (P = .004); Tg− vs Tg−; Fe def (P = .11); Tg+ vs Tg−; Fe def (P < .001).
S:L ratio: Tg− vs Tg+ (P < .001); Tg− vs Tg−; Fe def (P = .99); Tg+ vs Tg−; Fe def (P < .001).