Pathologic and genetic features that can facilitate the distinction between BL, BCLU, and DLBCL4
*Approximately 5% of otherwise classical BL cases lack a detectable MYC rearrangement.
†IG-MYC: juxtaposition of MYC to one of the IG loci: IGH@ at 14q32, IGK@ at 2p12, or IGL@ at 22q11. Non-IG-MYC tumors contain an MYC rearrangement but no juxtaposition to one of the IG loci.
‡DHLs contain an MYC/8q24 translocation in combination with a BCL2/18q21 (most frequent) and/or BCL6/3q27 translocation. The partner of BCL2/18q21 is mostly the IGH@ locus at 14q32.
§Simple karyotype: no or only few cytogenetic or (array) comparative genomic hybridization abnormalities other than the MYC rearrangement. For array comparative genomic hybridization, a lymphoma with 6 or more abnormalities has been assigned as “MYC-complex.”