Classification of chemotherapeutic agents by mechanism of action modified according to Smith et al6
| Mechanism of action/substance group . | Agent . |
|---|---|
| Alkylating agents | |
| Nitrogen mustard | Chlorambucil, cyclophosphamide, ifosfamide, melphalan |
| Nitrosourea | Carmustine, lomustine |
| Platinum-based | Carboplatin, cisplatin, oxaliplatin |
| Alkylsulfonate | Busulfan, treosulfan |
| Hydrazine | Procarbazine |
| Triazene | Dacarbazine |
| Aziridine | Thiotepa |
| Antimetabolites | |
| Folic acid | Methotrexate |
| Purine antagonist | Cladribine, clofarabine, fludarabine, mercaptopurine |
| Pyrimidine antagonist | Cytarabine, decitabine, azacitidine, fluorouracil, gemcitabine |
| Antitubulin | |
| Taxane | Docetaxel, paclitaxel |
| Vinca alkaloid | Vinblastine, vincristine, vindesine, vinorelbine |
| Topoisomerase II inhibitors | |
| Epipodophyllotoxin | Etoposide, teniposide |
| Intercalating agents | |
| Anthracycline29,30 | Daunorubicin, doxorubicin, epirubicin, idarubicin |
| Anthracenedione31,32 | Mitoxantrone |
| Streptomyces33 | Actinomycin, bleomycin, mitomycin |
| Mechanism of action/substance group . | Agent . |
|---|---|
| Alkylating agents | |
| Nitrogen mustard | Chlorambucil, cyclophosphamide, ifosfamide, melphalan |
| Nitrosourea | Carmustine, lomustine |
| Platinum-based | Carboplatin, cisplatin, oxaliplatin |
| Alkylsulfonate | Busulfan, treosulfan |
| Hydrazine | Procarbazine |
| Triazene | Dacarbazine |
| Aziridine | Thiotepa |
| Antimetabolites | |
| Folic acid | Methotrexate |
| Purine antagonist | Cladribine, clofarabine, fludarabine, mercaptopurine |
| Pyrimidine antagonist | Cytarabine, decitabine, azacitidine, fluorouracil, gemcitabine |
| Antitubulin | |
| Taxane | Docetaxel, paclitaxel |
| Vinca alkaloid | Vinblastine, vincristine, vindesine, vinorelbine |
| Topoisomerase II inhibitors | |
| Epipodophyllotoxin | Etoposide, teniposide |
| Intercalating agents | |
| Anthracycline29,30 | Daunorubicin, doxorubicin, epirubicin, idarubicin |
| Anthracenedione31,32 | Mitoxantrone |
| Streptomyces33 | Actinomycin, bleomycin, mitomycin |