Demographic and phenotypic characteristics in patients with SS
| Patient no. . | Age, y/sex . | Diagnosis . | TCR clone (%)* . | Tumor burden expression, % . | |||
|---|---|---|---|---|---|---|---|
| CD4+CD26− . | CD3+CD4+, %/μL . | CD3+CD8+ . | CD4+SD4+ . | ||||
| 1 | 73/M | SS/MF IVA | Vβ 18.0 (98) | 83.4 | 93.2/1968 | 1.8 | 92.4 |
| 2 | 80/M | SS/MF IVB | Vβ 13.6 (98) | 74.8 | 89.8/5496 | 2.4 | 82.5 |
| 3A | 76/M | SS/MF III | Vβ 7.2 (89.0) | 79.5 | 84.2/1061 | 2.8 | 94.7 |
| 3B | 75/M | SS | Vβ 7.2 (88) | 79.6 | 84.4/1464 | 1.8 | 71.4 |
| 4 | 71/M | SS IVA | Vβ 17 (94) | 17.9 68.1 (CD26+) | 80.9/1573 | 10.4 | 60.9 |
| 5 | 75/F | SS IVB | αβ (91.5) | 80.4 | 84.9/1467 | 8.7 | 81.1 |
| 6 | 67/F | SS IVB | Vβ 2.0 (98) | 90.9 | 93.0/8229 | 4.0 | 71.0 |
| 7 | 56/M | SS IVB | ND | 33.8 | ND | 13.3 | 32.0 |
| 8 | 62/M | SS IVB | ND | 24.9 | ND | 10.3 | 23.0 |
| Patient no. . | Age, y/sex . | Diagnosis . | TCR clone (%)* . | Tumor burden expression, % . | |||
|---|---|---|---|---|---|---|---|
| CD4+CD26− . | CD3+CD4+, %/μL . | CD3+CD8+ . | CD4+SD4+ . | ||||
| 1 | 73/M | SS/MF IVA | Vβ 18.0 (98) | 83.4 | 93.2/1968 | 1.8 | 92.4 |
| 2 | 80/M | SS/MF IVB | Vβ 13.6 (98) | 74.8 | 89.8/5496 | 2.4 | 82.5 |
| 3A | 76/M | SS/MF III | Vβ 7.2 (89.0) | 79.5 | 84.2/1061 | 2.8 | 94.7 |
| 3B | 75/M | SS | Vβ 7.2 (88) | 79.6 | 84.4/1464 | 1.8 | 71.4 |
| 4 | 71/M | SS IVA | Vβ 17 (94) | 17.9 68.1 (CD26+) | 80.9/1573 | 10.4 | 60.9 |
| 5 | 75/F | SS IVB | αβ (91.5) | 80.4 | 84.9/1467 | 8.7 | 81.1 |
| 6 | 67/F | SS IVB | Vβ 2.0 (98) | 90.9 | 93.0/8229 | 4.0 | 71.0 |
| 7 | 56/M | SS IVB | ND | 33.8 | ND | 13.3 | 32.0 |
| 8 | 62/M | SS IVB | ND | 24.9 | ND | 10.3 | 23.0 |
Patients (Pt.) with SS ranged in age from 56 to 80 years with median age of 70 years, and forming 2 groups: Pt. 1 through Pt. 6 who had high tumor burden (CD4+CD26− T cells was ≥ 74.8%) and Pt. 7 and Pt. 8 who had low tumor burden (≤ 33.8%). Tumor burden of Pt. 4 was much less (CD4+CD26− 17.9%) but with 68.1% of CD4+CD26+ T cells.
IVA indicates stage IV A SS; IVB, stage IV B SS; and ND, not determined.
All patients were shown to have a TCR clone except for Pt. 5, Pt. 7, and Pt. 8 in whom the procedure was not performed. Pt. 3A and Pt. 3B are the same patient, whose samples were taken at different times during progression of disease.