The production of IL-9 was decreased by a monoclonal anti–IL-2R-α antibody in ex vivo cultures of PBMCs from a patient with smoldering/chronic ATL
PBMC culture . | IL-2 (pg/mL) . | IL-9 (pg/mL) . | ||
---|---|---|---|---|
Without anti–IL-2R-α . | With anti–IL-2R-α . | Without anti–IL-2R-α . | With anti–IL-2R-α . | |
Day 1 | 585 | 528 | Not detected* | Not detected* |
Day 2 | 954 | 957 | 46 | Not detected* |
Day 3 | 1048 | 1170 | 146 | Not detected* |
Day 4 | 1138 | 1424 | 196 | Not detected* |
Day 5 | 1156 | 1633 | 287 | Not detected* |
Day 6 | 1196 | 1704 | 532 | Not detected* |
PBMC culture . | IL-2 (pg/mL) . | IL-9 (pg/mL) . | ||
---|---|---|---|---|
Without anti–IL-2R-α . | With anti–IL-2R-α . | Without anti–IL-2R-α . | With anti–IL-2R-α . | |
Day 1 | 585 | 528 | Not detected* | Not detected* |
Day 2 | 954 | 957 | 46 | Not detected* |
Day 3 | 1048 | 1170 | 146 | Not detected* |
Day 4 | 1138 | 1424 | 196 | Not detected* |
Day 5 | 1156 | 1633 | 287 | Not detected* |
Day 6 | 1196 | 1704 | 532 | Not detected* |
The data represent 2 independent experiments.
The level of IL-9 was < 1 pg/mL.