Cox regression analysis of WT1 mutations and other specific prognostic factors
| . | EFS from study entry . | RFS from end of course 1 . | ||||||
|---|---|---|---|---|---|---|---|---|
| N . | HR . | 95% CI . | P . | N . | HR . | 95% CI . | P . | |
| Univariate Cox analyses | ||||||||
| WT1 mutation present (vs absent) | 70 | 1.50 | 1.10-2.05 | .011 | 49 | 1.49 | 0.94-2.36 | .092 |
| High-risk cytogenetic/molecular (vs standard) | 123 | 1.79 | 1.4-2.28 | < .001 | 79 | 1.94 | 1.39-2.72 | < .001 |
| Favorable-risk cytogenetic/molecular (vs standard) | 249 | 0.51 | 0.40-0.66 | < .001 | 227 | 0.47 | 0.34-0.65 | < .001 |
| WBC count greater than 50 × 109/L (vs less than 50 × 109/L | 388 | 1.32 | 1.13-1.56 | < .001 | 283 | 1.26 | 1.00-1.58 | .047 |
| Multivariate Cox analyses | ||||||||
| WT1 mutation present (vs absent) | 59 | 1.33 | 0.94-1.88 | .105 | 41 | 1.33 | 0.81-2.20 | .261 |
| High-risk cytogenetic/molecular (vs standard) | 98 | 1.52 | 1.14-2.04 | .004 | 63 | 1.93 | 1.29-2.89 | .002 |
| Favorable-risk cytogenetic/molecular (vs standard) | 189 | 0.50 | 0.38-0.66 | < .001 | 171 | 0.48 | 0.32-0.70 | < .001 |
| WBC count greater than 50 × 109/L (vs less than 50 × 109/L) | 212 | 1.35 | 1.08-1.69 | .010 | 151 | 1.26 | 0.91-1.74 | .158 |
| . | EFS from study entry . | RFS from end of course 1 . | ||||||
|---|---|---|---|---|---|---|---|---|
| N . | HR . | 95% CI . | P . | N . | HR . | 95% CI . | P . | |
| Univariate Cox analyses | ||||||||
| WT1 mutation present (vs absent) | 70 | 1.50 | 1.10-2.05 | .011 | 49 | 1.49 | 0.94-2.36 | .092 |
| High-risk cytogenetic/molecular (vs standard) | 123 | 1.79 | 1.4-2.28 | < .001 | 79 | 1.94 | 1.39-2.72 | < .001 |
| Favorable-risk cytogenetic/molecular (vs standard) | 249 | 0.51 | 0.40-0.66 | < .001 | 227 | 0.47 | 0.34-0.65 | < .001 |
| WBC count greater than 50 × 109/L (vs less than 50 × 109/L | 388 | 1.32 | 1.13-1.56 | < .001 | 283 | 1.26 | 1.00-1.58 | .047 |
| Multivariate Cox analyses | ||||||||
| WT1 mutation present (vs absent) | 59 | 1.33 | 0.94-1.88 | .105 | 41 | 1.33 | 0.81-2.20 | .261 |
| High-risk cytogenetic/molecular (vs standard) | 98 | 1.52 | 1.14-2.04 | .004 | 63 | 1.93 | 1.29-2.89 | .002 |
| Favorable-risk cytogenetic/molecular (vs standard) | 189 | 0.50 | 0.38-0.66 | < .001 | 171 | 0.48 | 0.32-0.70 | < .001 |
| WBC count greater than 50 × 109/L (vs less than 50 × 109/L) | 212 | 1.35 | 1.08-1.69 | .010 | 151 | 1.26 | 0.91-1.74 | .158 |