Table 3 Estimated PK parameters Compound... | American Society of Hematology

Table 3

Estimated PK parameters

Compound	Comp	Cl, mL/h per kg	V₁, mL/kg	V₂, mL/kg	t_{1/2 alfa}, h	t_{1/2 beta}, h	MRT, h
FVII	2	609	304	336	0.19	1.4	1.0
FVII_X	2	176	244	966	0.10	6.3	6.6
FX	2	25	105	102	0.08	8.6	6.3
FXa_i	1	354	216			0.42	0.6
FVII_X_HC	2	82	194	305	0.12	5.4	5.5
FVII_X_1-34	2	249	228	490	0.15	3.6	2.6
FVII_X_30-52	2	295	246	1080	0.13	4.2	4.4
FVII_X_NNAA	2	115	173	259	0.16	3.8	3.4
FVII_X_TTAA	2	146	200	747	0.11	5.7	6.3

Compound	Comp	Cl, mL/h per kg	V₁, mL/kg	V₂, mL/kg	t_{1/2 alfa}, h	t_{1/2 beta}, h	MRT, h
FVII	2	609	304	336	0.19	1.4	1.0
FVII_X	2	176	244	966	0.10	6.3	6.6
FX	2	25	105	102	0.08	8.6	6.3
FXa_i	1	354	216			0.42	0.6
FVII_X_HC	2	82	194	305	0.12	5.4	5.5
FVII_X_1-34	2	249	228	490	0.15	3.6	2.6
FVII_X_30-52	2	295	246	1080	0.13	4.2	4.4
FVII_X_NNAA	2	115	173	259	0.16	3.8	3.4
FVII_X_TTAA	2	146	200	747	0.11	5.7	6.3

NMRI mice were dosed 1 mg/kg of the listed compounds intravenously.

Comp indicates the estimated number of compartments in the pharmacokinetic model; Cl, clearance; V₁, central compartment; V₂, peripheral compartment; t_1/2alpha, distribution half-life; t_1/2beta, terminal half-life; and MRT, mean residence time.

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