Summary of inhibitor eradication in hemophilia A dogs following cFVIII expression by AAV vector
| Dog . | Age, y . | Weight, kg . | Inhibitors . | cFVIII plateau, activity . | Bleeds per month . | |||
|---|---|---|---|---|---|---|---|---|
| Duration before treatment, mo . | Historical peak, BU . | Time to eradication, wk . | Pretreatment . | Posttreatment . | ||||
| K01 | 1.7 | 20.1 | 8 | 12 | 5 | 1.5 % | 3/20 | 1/23 |
| K03 | 1 | 19.3 | 7 | 12 | 4 | 8 % | 7/12 | 1/29 |
| L44 | 0.7 | 16 | 4 | 4.5 | 4 | 1.5 % | 5/8 | 0/16 |
| Wembley | 4.92 | 16.5 | ∼ 24 | 3.6 | 80 | |||
| Total | 15/40 | 2/68 | ||||||
| Dog . | Age, y . | Weight, kg . | Inhibitors . | cFVIII plateau, activity . | Bleeds per month . | |||
|---|---|---|---|---|---|---|---|---|
| Duration before treatment, mo . | Historical peak, BU . | Time to eradication, wk . | Pretreatment . | Posttreatment . | ||||
| K01 | 1.7 | 20.1 | 8 | 12 | 5 | 1.5 % | 3/20 | 1/23 |
| K03 | 1 | 19.3 | 7 | 12 | 4 | 8 % | 7/12 | 1/29 |
| L44 | 0.7 | 16 | 4 | 4.5 | 4 | 1.5 % | 5/8 | 0/16 |
| Wembley | 4.92 | 16.5 | ∼ 24 | 3.6 | 80 | |||
| Total | 15/40 | 2/68 | ||||||