Table 1 Genotype frequencies and the... | American Society of Hematology

Table 1

Genotype frequencies and the rate of major molecular response at 12 months in the French SPIRIT study

ABCB1 genotypes, all patients	Imatinib 400 mg			Imatinib 400 mg + IFN			Imatinib 400 mg + AraC			Imatinib 600 mg
ABCB1 genotypes, all patients	GF (%)	% MMR	P	GF (%)	% MMR	P	GF (%)	% MMR	P	GF (%)	% MMR	P
C1236T (N = 510)	n = 133		.85	n = 122		.56	n = 126		.16	n = 129		.28
CC	34.6	43.5		27.9	58.8		32.5	65.9		40.3	53.8
CT	45.1	41.7		49.2	61.7		45.2	54.4		40.3	65.4
TT	20.3	48.1		23	71.4		22.2	42.9		19.4	48
G2677T/A (N = 537)	n = 133		.93	n = 134		.56	n = 136		.06	n = 134		.24
GG	39.1	44.2		30.6	58.5		38.2	59.6		38.8	51.9
GT	41.4	41.8		47.8	68.8		41.9	57.9		44	62.7
TT	19.5	46.2		21.6	65.5		19.9	33.3		17.2	43.5
C3435T (N = 557)	n = 139		.20	n = 139		.71	n = 139		.33	n = 140		.84
CC	23.7	51.5		21.1	71.4		32.4	62.2		27.1	57.9
CT	49.6	36.2		48.2	62.7		42.4	52.5		45	55.6
TT	26.6	51.4		31.7	63.6		25.2	45.7		27.9	51.3

ABCB1 genotypes, all patients	Imatinib 400 mg			Imatinib 400 mg + IFN			Imatinib 400 mg + AraC			Imatinib 600 mg
ABCB1 genotypes, all patients	GF (%)	% MMR	P	GF (%)	% MMR	P	GF (%)	% MMR	P	GF (%)	% MMR	P
C1236T (N = 510)	n = 133		.85	n = 122		.56	n = 126		.16	n = 129		.28
CC	34.6	43.5		27.9	58.8		32.5	65.9		40.3	53.8
CT	45.1	41.7		49.2	61.7		45.2	54.4		40.3	65.4
TT	20.3	48.1		23	71.4		22.2	42.9		19.4	48
G2677T/A (N = 537)	n = 133		.93	n = 134		.56	n = 136		.06	n = 134		.24
GG	39.1	44.2		30.6	58.5		38.2	59.6		38.8	51.9
GT	41.4	41.8		47.8	68.8		41.9	57.9		44	62.7
TT	19.5	46.2		21.6	65.5		19.9	33.3		17.2	43.5
C3435T (N = 557)	n = 139		.20	n = 139		.71	n = 139		.33	n = 140		.84
CC	23.7	51.5		21.1	71.4		32.4	62.2		27.1	57.9
CT	49.6	36.2		48.2	62.7		42.4	52.5		45	55.6
TT	26.6	51.4		31.7	63.6		25.2	45.7		27.9	51.3

GF indicates genotype frequency; and MMR, rate of major molecular response.