Table 2

Typical symptoms and findings in various categories of SM

Symptom/findingTypically found in
ISMSSMASMMCL
Mediator-related     
    Hypotension and shock +/− +/− 
    Peptic ulcer disease +/− +/− +/− +/− 
    Headache and diarrhea 
Organ-specific     
    Maculopapular skin lesions +/− −/+ 
    Osteopenia/osteoporosis +/− +/− −/+ − 
B-findings     
    Hepatosplenomegaly − +/− +/− 
    Lymphadenopathy − +/− +/− −/+ 
    Myeloproliferation or dysplasia − +/− +/− −/+ 
C-findings     
    Marked cytopenia − − 
    Osteolysis with or without pathologic fractures − − 
    Ascites and elevated liver enzymes − − 
    Malabsorption plus hypoalbuminemia − − 
Symptom/findingTypically found in
ISMSSMASMMCL
Mediator-related     
    Hypotension and shock +/− +/− 
    Peptic ulcer disease +/− +/− +/− +/− 
    Headache and diarrhea 
Organ-specific     
    Maculopapular skin lesions +/− −/+ 
    Osteopenia/osteoporosis +/− +/− −/+ − 
B-findings     
    Hepatosplenomegaly − +/− +/− 
    Lymphadenopathy − +/− +/− −/+ 
    Myeloproliferation or dysplasia − +/− +/− −/+ 
C-findings     
    Marked cytopenia − − 
    Osteolysis with or without pathologic fractures − − 
    Ascites and elevated liver enzymes − − 
    Malabsorption plus hypoalbuminemia − − 

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