Table 1 Anti-CD19 CAR-transduced T cells... | American Society of Hematology

Table 1

Anti-CD19 CAR-transduced T cells produced IFN-γ specifically in response to CD19

Effector T cells*	CD19⁺ targets			CD19⁻ targets			Effectors alone
Effector T cells*	38c13	CD19-K562	Splenocytes	Sol8	CCL12	NGFR-K562	Effectors alone
1D3–28Z.1-3	286 480	234 252	16 378	1224	969	1531	1126
1D3–28Z	294 150	297 100	18 085	5892	4480	6055	6267
Not transduced	211	123	292	178	129	124	122

Effector T cells*	CD19⁺ targets			CD19⁻ targets			Effectors alone
Effector T cells*	38c13	CD19-K562	Splenocytes	Sol8	CCL12	NGFR-K562	Effectors alone
1D3–28Z.1-3	286 480	234 252	16 378	1224	969	1531	1126
1D3–28Z	294 150	297 100	18 085	5892	4480	6055	6267
Not transduced	211	123	292	178	129	124	122

Values are the means of duplicate wells. The units are in picograms per milliliter of IFN-γ. All target cells cultured alone produced undetectable levels of IFN-γ.

Effector T cells were transduced with the indicated CAR as described in Figure 1C. Cultures containing the indicated effector cells and target cells were set up 1 day after transductions were completed.

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