Complications of transplantation in patients with Crohn disease
| Patient . | Days of fever* . | Infections during hospitalization . | Infections during first year after HSCT . | Other complications . |
|---|---|---|---|---|
| 1 | NA | None | Line sepsis | Accidental death 3 years after HSCT |
| 2 | 4 | None | Flu-like syndrome GI | Nausea grade III, vomiting, diarrhea |
| 3 | 3 | S aureus coag neg UTI | Abdominal abscess (Klebsiella pneumonia, S aureus coag neg) after surgery | Mild nausea and anorexia, pulmonary edema (fluid overload) |
| 4 | 1 | None | Vaginal Candida | No grade III or grade IV |
| 5 | 3 | MRSA abscess near anal fistula | URTI | No grade III or grade IV |
| 6 | 16 | Candida in stool | None | Grade III nausea and anorexia, diarrhea, fluid overload |
| 7 | 3 | None | None | Grade III nausea, grade III and grade IV anorexia, abdominal pain, depression |
| 8 | 3 | S aureus in surveillance nasal culture | Mild URTI Stomach flu–like syndrome EBV (14 months after HSCT) | No III or IV toxicities |
| 9 | 2 | S aureus in surveillance nasal culture S aureus UTI | None | Grade III hematemesis, sepsis (ICU), pulmonary edema, pleural effusion |
| 10 | 7 | None | UTI | Grade I and grade II nausea, vomiting and diarrhea Pulmonary aspergillosis 2 years after HSCT |
| 11 | 6 | None | None | Grade I and grade II nausea, vomiting, diarrhea, abdominal pain |
| 12 | 7 | None | None | Grade I nausea, vomiting, diarrhea, grade III abdominal and perianal pain |
| 13 | 3 | None | None | Hemostasis, tachycardia, dyspnea, hematemesis, grade II nausea and vomiting, abdominal pain, fluid overload |
| 14 | 2 | None | None | Nausea, vomiting, abdominal pain, diarrhea |
| 15 | 0 | 1 BC + for GPC (contaminant) | None | Grade III diarrhea |
| 16 | 4 | BC + Klebsiella | None | Diarrhea, nausea, vomiting fluid overload |
| 17 | 1 | BC + S aureus coag neg | None | Asthenia |
| 18 | 0 | None | UTI | Grade II abdominal pain and fatigue |
| 19 | 1 | BC + S aureus coag neg Urine culture + yeast nonalbicans | Urosepsis (neg cultures) UTI + E coli | Severe abdominal pain and diarrhea |
| 20 | 0 | None (Candida albicans and glabrata sepsis secondary to line infection and line-related MRSA bacteriemia after mobilization before HSCT) | Sepsis (BC + GPC) VRE bacteriemia (BC + GPC) | Mild nausea, abdominal pain |
| 21 | 0 | None | Shingles (VZV) Pneumonia (mycobacterium atypical) | None |
| 22 | 0 | Folliculitis | None | None |
| 23 | 0 | None | CMV viremia (no disease) | None |
| 24 | 4 | Blood-E faecium Rectal-VRE | None | Perirectal abscess ID/seton |
| Patient . | Days of fever* . | Infections during hospitalization . | Infections during first year after HSCT . | Other complications . |
|---|---|---|---|---|
| 1 | NA | None | Line sepsis | Accidental death 3 years after HSCT |
| 2 | 4 | None | Flu-like syndrome GI | Nausea grade III, vomiting, diarrhea |
| 3 | 3 | S aureus coag neg UTI | Abdominal abscess (Klebsiella pneumonia, S aureus coag neg) after surgery | Mild nausea and anorexia, pulmonary edema (fluid overload) |
| 4 | 1 | None | Vaginal Candida | No grade III or grade IV |
| 5 | 3 | MRSA abscess near anal fistula | URTI | No grade III or grade IV |
| 6 | 16 | Candida in stool | None | Grade III nausea and anorexia, diarrhea, fluid overload |
| 7 | 3 | None | None | Grade III nausea, grade III and grade IV anorexia, abdominal pain, depression |
| 8 | 3 | S aureus in surveillance nasal culture | Mild URTI Stomach flu–like syndrome EBV (14 months after HSCT) | No III or IV toxicities |
| 9 | 2 | S aureus in surveillance nasal culture S aureus UTI | None | Grade III hematemesis, sepsis (ICU), pulmonary edema, pleural effusion |
| 10 | 7 | None | UTI | Grade I and grade II nausea, vomiting and diarrhea Pulmonary aspergillosis 2 years after HSCT |
| 11 | 6 | None | None | Grade I and grade II nausea, vomiting, diarrhea, abdominal pain |
| 12 | 7 | None | None | Grade I nausea, vomiting, diarrhea, grade III abdominal and perianal pain |
| 13 | 3 | None | None | Hemostasis, tachycardia, dyspnea, hematemesis, grade II nausea and vomiting, abdominal pain, fluid overload |
| 14 | 2 | None | None | Nausea, vomiting, abdominal pain, diarrhea |
| 15 | 0 | 1 BC + for GPC (contaminant) | None | Grade III diarrhea |
| 16 | 4 | BC + Klebsiella | None | Diarrhea, nausea, vomiting fluid overload |
| 17 | 1 | BC + S aureus coag neg | None | Asthenia |
| 18 | 0 | None | UTI | Grade II abdominal pain and fatigue |
| 19 | 1 | BC + S aureus coag neg Urine culture + yeast nonalbicans | Urosepsis (neg cultures) UTI + E coli | Severe abdominal pain and diarrhea |
| 20 | 0 | None (Candida albicans and glabrata sepsis secondary to line infection and line-related MRSA bacteriemia after mobilization before HSCT) | Sepsis (BC + GPC) VRE bacteriemia (BC + GPC) | Mild nausea, abdominal pain |
| 21 | 0 | None | Shingles (VZV) Pneumonia (mycobacterium atypical) | None |
| 22 | 0 | Folliculitis | None | None |
| 23 | 0 | None | CMV viremia (no disease) | None |
| 24 | 4 | Blood-E faecium Rectal-VRE | None | Perirectal abscess ID/seton |
BC indicates blood culture; coag, coagulase; CMV, cytomegalovirus; EBV, Epstein-Barr virus; E coli, Escherichia coli; E faecium, Enterococcus faecium; ICU, intensive care unit; ID, incision and drainage; GI, gastrointestinal; GPC, Gram-positive cocci; MRSA, methicillin-resistant Staphylococcus aureus; neg, negative; NA, not available; S aureus, Staphylococcus aureus; staph, staphylococcus; URTI, upper respiratory tract infection; UTI, urinary tract infection; VRE, vancomycin-resistant enterococcus; and VZV, varicella zoster virus.
Fever defined as > 100.5°F.