Table 2

Genes differentiatially regulated by IFN-α and LPS with putative antiviral activity

Probe set IDGene titleGene symbolFC, IFN-α/C*FC, LPS/C
204698_at Interferon-stimulated exonuclease gene 20 kDa ISG20 78.24 4.18 
205483_s_at ISG15 ubiquitin-like modifier ISG15 41.89 6.79 
219424_at Epstein-Barr virus induced gene 3 EBI3 41.76 3.09 
33304_at Interferon-stimulated exonuclease gene 20 kDa ISG20 38.35 3.6 
205660_at 2′-5′-oligoadenylate synthetase-like OASL 33.49 6.54 
214038_at Chemokine (C-C motif) ligand 8 CCL8 24.34 2.4 
210797_s_at 2′-5′-oligoadenylate synthetase-like OASL 17.41 3.68 
202086_at Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) MX1 14.27 0.88 
210873_x_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3A 7.38 1.07 
204972_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 6.38 1.02 
204994_at Myxovirus (influenza virus) resistance 2 (mouse) MX2 5.33 1.18 
202869_at 2′,5′-oligoadenylate synthetase 1, 40/46 kDa OAS1 4.88 0.84 
218400_at 2′-5′-oligoadenylate synthetase 3, 100 kDa OAS3 4.63 1.25 
205552_s_at 2′,5′-oligoadenylate synthetase 1, 40/46 kDa OAS1 4.28 0.92 
231876_at Tripartite motif-containing 56 TRIM56 3.46 1.24 
219736_at Tripartite motif-containing 36 TRIM36 3.06 1.3 
224806_at Tripartite motif-containing 25 TRIM25 3.05 0.83 
206553_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 2.8 1.01 
204205_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G APOBEC3G 2.68 0.96 
213293_s_at Tripartite motif-containing 22 TRIM22 2.66 1.12 
204804_at Tripartite motif-containing 21 TRIM21 2.56 1.18 
206911_at Tripartite motif-containing 25 TRIM25 2.53 1.2 
210705_s_at Tripartite motif-containing 5 TRIM5 2.37 0.97 
232666_at 2′-5′-oligoadenylate synthetase 3, 100 kDa OAS3 2.32 1.14 
224984_at Nuclear factor of activated T cells 5, tonicity-responsive NFAT5 2.14 1.04 
223830_s_at Tripartite motif-containing 5 TRIM5 1.83 1.31 
203665_at Heme oxygenase (decycling) 1 HMOX1 1.75 0.77 
228607_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 1.6 1.08 
1565814_at Tripartite motif-containing 36 TRIM36 1.34 1.34 
214994_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3F 1.24 1.12 
208003_s_at Nuclear factor of activated T cells 5, tonicity-responsive NFAT5 1.23 0.8 
1565812_at Tripartite motif-containing 36 TRIM36 1.13 1.16 
243912_x_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3F 1.1 1.02 
215092_s_at Nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 1.05 0.89 
231123_at Tripartite motif-containing 36 TRIM36 1.05 0.93 
215579_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G APOBEC3G 1.04 1.1 
Probe set IDGene titleGene symbolFC, IFN-α/C*FC, LPS/C
204698_at Interferon-stimulated exonuclease gene 20 kDa ISG20 78.24 4.18 
205483_s_at ISG15 ubiquitin-like modifier ISG15 41.89 6.79 
219424_at Epstein-Barr virus induced gene 3 EBI3 41.76 3.09 
33304_at Interferon-stimulated exonuclease gene 20 kDa ISG20 38.35 3.6 
205660_at 2′-5′-oligoadenylate synthetase-like OASL 33.49 6.54 
214038_at Chemokine (C-C motif) ligand 8 CCL8 24.34 2.4 
210797_s_at 2′-5′-oligoadenylate synthetase-like OASL 17.41 3.68 
202086_at Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) MX1 14.27 0.88 
210873_x_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3A 7.38 1.07 
204972_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 6.38 1.02 
204994_at Myxovirus (influenza virus) resistance 2 (mouse) MX2 5.33 1.18 
202869_at 2′,5′-oligoadenylate synthetase 1, 40/46 kDa OAS1 4.88 0.84 
218400_at 2′-5′-oligoadenylate synthetase 3, 100 kDa OAS3 4.63 1.25 
205552_s_at 2′,5′-oligoadenylate synthetase 1, 40/46 kDa OAS1 4.28 0.92 
231876_at Tripartite motif-containing 56 TRIM56 3.46 1.24 
219736_at Tripartite motif-containing 36 TRIM36 3.06 1.3 
224806_at Tripartite motif-containing 25 TRIM25 3.05 0.83 
206553_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 2.8 1.01 
204205_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G APOBEC3G 2.68 0.96 
213293_s_at Tripartite motif-containing 22 TRIM22 2.66 1.12 
204804_at Tripartite motif-containing 21 TRIM21 2.56 1.18 
206911_at Tripartite motif-containing 25 TRIM25 2.53 1.2 
210705_s_at Tripartite motif-containing 5 TRIM5 2.37 0.97 
232666_at 2′-5′-oligoadenylate synthetase 3, 100 kDa OAS3 2.32 1.14 
224984_at Nuclear factor of activated T cells 5, tonicity-responsive NFAT5 2.14 1.04 
223830_s_at Tripartite motif-containing 5 TRIM5 1.83 1.31 
203665_at Heme oxygenase (decycling) 1 HMOX1 1.75 0.77 
228607_at 2′-5′-oligoadenylate synthetase 2, 69/71 kDa OAS2 1.6 1.08 
1565814_at Tripartite motif-containing 36 TRIM36 1.34 1.34 
214994_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3F 1.24 1.12 
208003_s_at Nuclear factor of activated T cells 5, tonicity-responsive NFAT5 1.23 0.8 
1565812_at Tripartite motif-containing 36 TRIM36 1.13 1.16 
243912_x_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3F 1.1 1.02 
215092_s_at Nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 1.05 0.89 
231123_at Tripartite motif-containing 36 TRIM36 1.05 0.93 
215579_at Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G APOBEC3G 1.04 1.1 

The 35 gene symbols were selected based on putative antiviral activities that are differentially regulated by IFN-α through IFNAR and LPS through toll-like receptors as fold change (FC; see “Methods”).

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