Table 2

Results of multivariate analysis of outcomes in 173 recipients of cord blood and 311 recipients of bone marrow with acute myeloid leukemia, and 114 recipients of cord blood and 222 recipients of bone marrow with acute lymphoblastic leukemia

OutcomeAcute myeloid leukemia
Acute lymphoblastic leukemia
RR (95% CI)PRR (95% CI)P
Overall survival*     
    BM 1.00  1.00  
    CB 1.45 (1.04-2.01) .028 1.06 (0.71-1.57) .78 
Leukemia-free survival     
    BM 1.00  1.00  
    CB 1.48 (1.09-2.01) .012 1.22 (0.85-1.76) .28 
Relapse     
    BM 1.00  1.00  
    CB 1.21 (0.79-1.87) .38 1.42 (0.84-2.41) .19 
TRM§     
    BM 1.00  1.00  
    CB 1.47 (0.95-2.28) .085 1.01 (0.59-1.73) .98 
Neutrophil recovery     
    BM 1.00  1.00  
    CB 0.41 (0.33-0.51) < .001 0.37 (0.29-0.48) < .001 
Platelet recovery     
    BM 1.00  1.00  
    CB 0.34 (0.27-0.44) < .001 0.43 (0.33-0.56) < .001 
Acute GVHD#     
    BM 1.00  1.00  
    CB 0.80 (0.56-1.15) .23 0.61 (0.39-0.95) .028 
Chronic GVHD**     
    BM 1.00  1.00  
    CB 0.94 (0.63-1.42) .79 1.08 (0.66-1.77) .77 
Chronic GVHD, extensive type††     
    BM 1.00  1.00  
    CB 0.36 (0.18-0.72) .004 0.58 (0.28-1.20) .14 
OutcomeAcute myeloid leukemia
Acute lymphoblastic leukemia
RR (95% CI)PRR (95% CI)P
Overall survival*     
    BM 1.00  1.00  
    CB 1.45 (1.04-2.01) .028 1.06 (0.71-1.57) .78 
Leukemia-free survival     
    BM 1.00  1.00  
    CB 1.48 (1.09-2.01) .012 1.22 (0.85-1.76) .28 
Relapse     
    BM 1.00  1.00  
    CB 1.21 (0.79-1.87) .38 1.42 (0.84-2.41) .19 
TRM§     
    BM 1.00  1.00  
    CB 1.47 (0.95-2.28) .085 1.01 (0.59-1.73) .98 
Neutrophil recovery     
    BM 1.00  1.00  
    CB 0.41 (0.33-0.51) < .001 0.37 (0.29-0.48) < .001 
Platelet recovery     
    BM 1.00  1.00  
    CB 0.34 (0.27-0.44) < .001 0.43 (0.33-0.56) < .001 
Acute GVHD#     
    BM 1.00  1.00  
    CB 0.80 (0.56-1.15) .23 0.61 (0.39-0.95) .028 
Chronic GVHD**     
    BM 1.00  1.00  
    CB 0.94 (0.63-1.42) .79 1.08 (0.66-1.77) .77 
Chronic GVHD, extensive type††     
    BM 1.00  1.00  
    CB 0.36 (0.18-0.72) .004 0.58 (0.28-1.20) .14 

RR indicates relative risk; CI, confidence interval; BM, bone marrow; CB, cord blood; and GVHD, graft-versus-host disease.

*

For overall survival, other significant variables for AML were patient age more than 45 years at transplantation, more advanced disease status at conditioning, M5/M6/M7 French-American-British classification, and female donor to male recipient donor-recipient sex mismatch; other significant variables for ALL were second or after complete remission disease status, more advanced disease status, and Philadelphia chromosome abnormality.

For leukemia-free survival, other significant variables for AML were patient age more than 45 years at transplantation, more advanced disease status at conditioning, M5/M6/M7 French-American-British classification, and female donor to male recipient donor-recipient sex mismatch; other significant variables for ALL were second or after complete remission disease status, more advanced disease status, and Philadelphia chromosome abnormality.

For relapse, other significant variables for AML were more advanced disease status at conditioning, donor-recipient ABO major mismatch, chromosome abnormality other than favorable abnormalities, and cyclophosphamide and total body irradiation or busulfan and cyclophosphamide conditioning regimen; other significant variables for ALL were second or after complete remission disease status, more advanced disease status, and cyclophosphamide and total body irradiation conditioning.

§

For TRM, other significant variables for AML were patient age more than 45 years at transplantation, second or after complete remission disease status, more advanced disease status, and chromosome abnormality other than favorable abnormalities; other significant variables for ALL were patient age more than 45 years at transplantation, more advanced disease status at conditioning, and conditioning other than cyclophosphamide and total body irradiation.

For neutrophil recovery, other significant variables for AML were second or after complete remission disease status and more advanced disease status; other significant variables for ALL were more advanced disease status at conditioning and cyclosporine-based GVHD prophylaxis.

For platelet recovery; other significant variables for AML were second or after complete remission disease status, more advanced disease status, female donor to male recipient donor-recipient sex mismatch, and tacrolimus-based GVHD prophylaxis; other significant variables for ALL were more advanced disease status at conditioning and conditioning other than cyclophosphamide and total body irradiation.

#

For acute GVHD, no other significant variables were identified for both AML and ALL.

**

For chronic GVHD, other significant variables for AML were more advanced disease status and conditioning other than cyclophosphamide and total body irradiation or busulfan and cyclophosphamide; there were no other significant variables identified for ALL.

††

For extensive chronic GVHD, there were no other significant variables identified for AML; another significant variable for ALL was patient male sex.

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