Comparison of neurocognitive test scores between patients randomized to either dexamethasone or prednisone
| Domain and instrument/scale . | Dexamethasone, LS means (SE)* . | Prednisone, LS means (SE) . | Difference† (95% CI) . | P . |
|---|---|---|---|---|
| Intelligence | ||||
| WISC-IV full scale IQ | 101.8 (1.7) | 101.6 (1.9) | 0.2 (−4.9-5.4) | .94 |
| Academic achievement | ||||
| WIAT II-A | ||||
| Word reading | 98.8 (1.7) | 104.9 (1.8) | −6.0 (−11.0 to −1.0) | .02‡ |
| Numeric operations | 100.6 (2.2) | 100.6 (2.5) | −0.1 (−6.8-6.6) | .99 |
| Spelling | 100.5 (1.8) | 104.5 (2.0) | −4.0 (−9.6-1.6) | .16 |
| Processing speed | ||||
| WISC-IV | ||||
| Processing speed index | 94.4 (1.8) | 92.6 (1.9) | 1.8 (−3.4-7.0) | .50 |
| Attention-concentration | ||||
| CPT-II | ||||
| Omissions | 45.4 (0.8) | 46.9 (0.9) | −1.4 (−6.3-3.1) | .25 |
| Commissions | 44.8 (1.6) | 46.4 (1.8) | −1.6 (6.3−3.1) | .50 |
| Reaction time | 47.4 (1.5) | 48.8 (1.6) | −1.4 (−5.8-3.1) | .54 |
| Variability T-score | 43.2 (1.2) | 45.4 (1.2) | −2.2 (−5.6-1.2) | .21 |
| Memory | ||||
| CMS | ||||
| Visual Immediate Index | 105.6 (1.8) | 103.0 (1.9) | 2.5 (−2.8-7.9) | .35 |
| Verbal immediate index | 106.0 (2.3) | 102.8 (2.5) | 3.2 (−3.2-10.1) | .36 |
| General memory index | 109.4 (2.1) | 106.0 (2.3) | 3.3 (−2.9-9.5) | .29 |
| Working memory | ||||
| WISC-IV | ||||
| Working memory | 98.2 (2.2) | 101.3 (2.4) | −3.0 (−9.4-3.3) | .34 |
| Visual motor integration | ||||
| Visual motor integration | 91.6 (1.7) | 95.2 (1.8) | −3.6 (−8.8-1.4) | .15 |
| Domain and instrument/scale . | Dexamethasone, LS means (SE)* . | Prednisone, LS means (SE) . | Difference† (95% CI) . | P . |
|---|---|---|---|---|
| Intelligence | ||||
| WISC-IV full scale IQ | 101.8 (1.7) | 101.6 (1.9) | 0.2 (−4.9-5.4) | .94 |
| Academic achievement | ||||
| WIAT II-A | ||||
| Word reading | 98.8 (1.7) | 104.9 (1.8) | −6.0 (−11.0 to −1.0) | .02‡ |
| Numeric operations | 100.6 (2.2) | 100.6 (2.5) | −0.1 (−6.8-6.6) | .99 |
| Spelling | 100.5 (1.8) | 104.5 (2.0) | −4.0 (−9.6-1.6) | .16 |
| Processing speed | ||||
| WISC-IV | ||||
| Processing speed index | 94.4 (1.8) | 92.6 (1.9) | 1.8 (−3.4-7.0) | .50 |
| Attention-concentration | ||||
| CPT-II | ||||
| Omissions | 45.4 (0.8) | 46.9 (0.9) | −1.4 (−6.3-3.1) | .25 |
| Commissions | 44.8 (1.6) | 46.4 (1.8) | −1.6 (6.3−3.1) | .50 |
| Reaction time | 47.4 (1.5) | 48.8 (1.6) | −1.4 (−5.8-3.1) | .54 |
| Variability T-score | 43.2 (1.2) | 45.4 (1.2) | −2.2 (−5.6-1.2) | .21 |
| Memory | ||||
| CMS | ||||
| Visual Immediate Index | 105.6 (1.8) | 103.0 (1.9) | 2.5 (−2.8-7.9) | .35 |
| Verbal immediate index | 106.0 (2.3) | 102.8 (2.5) | 3.2 (−3.2-10.1) | .36 |
| General memory index | 109.4 (2.1) | 106.0 (2.3) | 3.3 (−2.9-9.5) | .29 |
| Working memory | ||||
| WISC-IV | ||||
| Working memory | 98.2 (2.2) | 101.3 (2.4) | −3.0 (−9.4-3.3) | .34 |
| Visual motor integration | ||||
| Visual motor integration | 91.6 (1.7) | 95.2 (1.8) | −3.6 (−8.8-1.4) | .15 |
Data are presented as least squares means obtained from multiple linear regression, adjusted for sex, age at diagnosis, and time elapsed since diagnosis.
Least squares means (standard error).
Difference in adjusted least squares means between dexamethasone and prednisone treatment groups.
Significant difference between dexamethasone and prednisone treatment groups at P<.05.