Causes of death after UCB transplantation based on the presence or absence of NK-cell alloreactivity in the GVHD direction
| Cause of death . | Myeloablative conditioning . | Reduced-intensity conditioning . | ||
|---|---|---|---|---|
| KIR-L mismatched (%) . | KIR-L matched (%) . | KIR-L mismatched (%) . | KIR-L matched (%) . | |
| Disease recurrence | 6 (33) | 23 (49) | 13 (62) | 17 (61) |
| Infection | 7 (39) | 5 (11) | 2 (9) | 1 (4) |
| GVHD | 2 (11) | 4 (8) | 3 (14) | 4 (14) |
| ARDS | 0 | 1 (2) | 0 | 0 |
| Graft failure | 2 (11) | 2 (4) | 0 | 0 |
| Organ failure | 1 (6) | 8 (17) | 1 (5) | 4 (14) |
| Secondary malignancy | 0 | 2 (4) | 0 | 2 (7) |
| Hemorrhage | 0 | 2 (4) | 2 (8) | 0 |
| Cause of death . | Myeloablative conditioning . | Reduced-intensity conditioning . | ||
|---|---|---|---|---|
| KIR-L mismatched (%) . | KIR-L matched (%) . | KIR-L mismatched (%) . | KIR-L matched (%) . | |
| Disease recurrence | 6 (33) | 23 (49) | 13 (62) | 17 (61) |
| Infection | 7 (39) | 5 (11) | 2 (9) | 1 (4) |
| GVHD | 2 (11) | 4 (8) | 3 (14) | 4 (14) |
| ARDS | 0 | 1 (2) | 0 | 0 |
| Graft failure | 2 (11) | 2 (4) | 0 | 0 |
| Organ failure | 1 (6) | 8 (17) | 1 (5) | 4 (14) |
| Secondary malignancy | 0 | 2 (4) | 0 | 2 (7) |
| Hemorrhage | 0 | 2 (4) | 2 (8) | 0 |
P values were calculated using a Freeman-Halton test. For myeloablative conditioning, all causes of death had P values of .16. For reduced-intensity conditioning, all causes of death had P values of .41.
UCB indicates umbilical cord blood; NK, natural killer; GVHD, graft-versus-host disease; KIR, killer-cell immunoglobulin–like receptor; and ARDS, adult respiratory distress syndrome.