Function of genes down-regulated by GATA1 in G1ME cells
| GO biologic process list . | Matches . | Fold excess . | P . |
|---|---|---|---|
| Immune response | 34 | 4.16 | 8.78 × 10−12 |
| Immune system process | 41 | 3.43 | 2.80 × 10−11 |
| Cell activation | 15 | 3.94 | .000010 |
| Leukocyte activation | 14 | 4.05 | .000014 |
| Lymphocyte activation | 13 | 4.27 | .000016 |
| Regulation of mononuclear cell proliferation | 6 | 9.83 | .000035 |
| Regulation of lymphocyte proliferation | 6 | 9.83 | .000035 |
| Regulation of lymphocyte activation | 8 | 6.50 | .000037 |
| Response to stimulus | 58 | 1.77 | .000042 |
| Mononuclear cell proliferation | 7 | 7.24 | .000057 |
| GO biologic process list . | Matches . | Fold excess . | P . |
|---|---|---|---|
| Immune response | 34 | 4.16 | 8.78 × 10−12 |
| Immune system process | 41 | 3.43 | 2.80 × 10−11 |
| Cell activation | 15 | 3.94 | .000010 |
| Leukocyte activation | 14 | 4.05 | .000014 |
| Lymphocyte activation | 13 | 4.27 | .000016 |
| Regulation of mononuclear cell proliferation | 6 | 9.83 | .000035 |
| Regulation of lymphocyte proliferation | 6 | 9.83 | .000035 |
| Regulation of lymphocyte activation | 8 | 6.50 | .000037 |
| Response to stimulus | 58 | 1.77 | .000042 |
| Mononuclear cell proliferation | 7 | 7.24 | .000057 |
The Gene Ontology biologic processes most overrepresented among the 300 genes whose expression in G1ME was most decreased by GATA-1 transduction are shown. For each category, the number of down-regulated genes falling into that category is given, the factor by which this number of matches exceeds the number expected by chance, and the probability that the result is nonrandom. All categories with P < .00005 are shown.