Mean virologic, histologic, and immunologic parameters, and pair-wise correlation with serum CXCL13 concentrations in HCV-infected patients without and with mixed cryoglobulinemia
| Parameter . | Mixed cryoglobulinemia . | |||||
|---|---|---|---|---|---|---|
| Without . | With . | |||||
| Mean plus orminus SD . | r . | P . | Mean plus or minus SD . | r . | P . | |
| Circulating HCV-RNA (IU/mL) | 1 100 238 ± 1 203 834 | 0.06 | .87 | 491 248 ± 655 695 | 0.17 | .54 |
| Severity of liver disease | ||||||
| Activity index | 5.7 ± 1.8 | 0.07 | .84 | 4.2 ± 2.2 | 0.08 | .83 |
| Stage | 2.9 ± 0.8 | 0.14 | .69 | 2.1 ± 0.78 | 0.39 | .29 |
| ALT (normal values, 30-65 IU/L) | 93 ± 50 | 0.54 | .09 | 75 ± 34 | 0.24 | .39 |
| Immunologic features | ||||||
| Cryocrit, % | — | — | — | 7.0 ± 7.8 | 0.11 | .68 |
| Serum IgM (normal values, 40-230 mg/dL) | 120 ± 56 | 0.49 | .71 | 545 ± 818 | 0.37 | .16 |
| Rheumatoid factor activity (normal values, ≤ 20 IU/mL) | 16 ± 9 | 0.7 | .88 | 1850 ± 2456 | 0.3 | .26 |
| Complement C4 (normal values, 20-40 mg/dL) | 22.9 | 0.78 | .67 | 7.0 ± 8.2 | 0.06 | .81 |
| Parameter . | Mixed cryoglobulinemia . | |||||
|---|---|---|---|---|---|---|
| Without . | With . | |||||
| Mean plus orminus SD . | r . | P . | Mean plus or minus SD . | r . | P . | |
| Circulating HCV-RNA (IU/mL) | 1 100 238 ± 1 203 834 | 0.06 | .87 | 491 248 ± 655 695 | 0.17 | .54 |
| Severity of liver disease | ||||||
| Activity index | 5.7 ± 1.8 | 0.07 | .84 | 4.2 ± 2.2 | 0.08 | .83 |
| Stage | 2.9 ± 0.8 | 0.14 | .69 | 2.1 ± 0.78 | 0.39 | .29 |
| ALT (normal values, 30-65 IU/L) | 93 ± 50 | 0.54 | .09 | 75 ± 34 | 0.24 | .39 |
| Immunologic features | ||||||
| Cryocrit, % | — | — | — | 7.0 ± 7.8 | 0.11 | .68 |
| Serum IgM (normal values, 40-230 mg/dL) | 120 ± 56 | 0.49 | .71 | 545 ± 818 | 0.37 | .16 |
| Rheumatoid factor activity (normal values, ≤ 20 IU/mL) | 16 ± 9 | 0.7 | .88 | 1850 ± 2456 | 0.3 | .26 |
| Complement C4 (normal values, 20-40 mg/dL) | 22.9 | 0.78 | .67 | 7.0 ± 8.2 | 0.06 | .81 |
HCV indicates hepatitis C virus; ALT, alanine aminotransferase; —, not applicable; and IgM, immunoglobulin M.