Table 1

In vitro cytokine secretion by splenic CD4+ T cells from naive mice, FVIII plasmid-only treated mice, and FVIII plasmid plus anti-ICOS–treated mice

In vitro stimulationTGF-β1, pg/mLIL-10, pg/mL
No stimulation   
    Naive control 112 ± 6 70 ± 2 
    FVIII plasmid only 116 ± 12 73 ± 3 
    FVIII plasmid + anti-ICOS 103 ± 87 498 ± 7§ 
FVIII stimulation   
    Naive control 221 ± 3 106 ± 33 
    FVIII plasmid only 521 ± 4*† 380 ± 40*† 
    FVIII plasmid + anti-ICOS 706 ± 55†‡ 1432 ± 40†§ 
In vitro stimulationTGF-β1, pg/mLIL-10, pg/mL
No stimulation   
    Naive control 112 ± 6 70 ± 2 
    FVIII plasmid only 116 ± 12 73 ± 3 
    FVIII plasmid + anti-ICOS 103 ± 87 498 ± 7§ 
FVIII stimulation   
    Naive control 221 ± 3 106 ± 33 
    FVIII plasmid only 521 ± 4*† 380 ± 40*† 
    FVIII plasmid + anti-ICOS 706 ± 55†‡ 1432 ± 40†§ 

*P < .05 versus naive control under FVIII stimulation.

†

P < .01 versus group with same treatment but under different stimulation regimens.

‡

P < .05 versus naive control and FVIII plasmid-only treated mice within same stimulation regimen.

§

P < .01 versus naive control and FVIII plasmid-only treated mice within same stimulation regimen.

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