Association of genomic status at 6q14.1-14.3 and 6q15-16.1 with early treatment response in 47 T-ALL
| . | MRD on day 78 . | Univariate logistic regression . | Multivariate logistic regression . | ||||
|---|---|---|---|---|---|---|---|
| Unfavorable . | Favorable . | P . | Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| 6q14.1-14.3 and 6q15-16.1 | |||||||
| Deletion | 6 | 1 | |||||
| Balanced or gained | 16 | 24 | .04 | 0.15 (0.02, 0.84) | .03 | 0.15 (0.01, 1.11) | .06 |
| NOTCH1 mutation status | |||||||
| Wild-type | 17 | 9 | |||||
| Mutated | 5 | 16 | .01 | 0.18 (0.05, 0.60) | .01 | 0.22 (0.05, 0.81) | .02 |
| T-cell immunophenotype | |||||||
| Cortical | 13 | 23 | |||||
| Noncortical* | 7 | 2 | .06 | 0.19 (0.03, 0.84) | .03 | 0.21 (0.03, 1.20) | .08 |
| . | MRD on day 78 . | Univariate logistic regression . | Multivariate logistic regression . | ||||
|---|---|---|---|---|---|---|---|
| Unfavorable . | Favorable . | P . | Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |
| 6q14.1-14.3 and 6q15-16.1 | |||||||
| Deletion | 6 | 1 | |||||
| Balanced or gained | 16 | 24 | .04 | 0.15 (0.02, 0.84) | .03 | 0.15 (0.01, 1.11) | .06 |
| NOTCH1 mutation status | |||||||
| Wild-type | 17 | 9 | |||||
| Mutated | 5 | 16 | .01 | 0.18 (0.05, 0.60) | .01 | 0.22 (0.05, 0.81) | .02 |
| T-cell immunophenotype | |||||||
| Cortical | 13 | 23 | |||||
| Noncortical* | 7 | 2 | .06 | 0.19 (0.03, 0.84) | .03 | 0.21 (0.03, 1.20) | .08 |
CI indicates confidence interval.
Noncortical, pro/pre (cyCD3+, CD7+, and CD1, and sCD3−), mature (CD1a−, sCD3+); cortical (CD1a+).