Table 4 Factor XI and other risk factors... | American Society of Hematology

Table 4

Factor XI and other risk factors in relation to risk of VTE: LITE

Factor XI > 157% (top quintile)	Additional risk factor*	No. of cases	No. of controls	OR (95% CI)†	RERI % (95% CI)
	D-dimer > 0.56 ng/mL
No	No	195	594	1 (reference)	−7% (−94% to +80%)
No	Yes	134	230	1.8 (1.3 to 2.4)
Yes	No	74	132	1.5 (1.1 to 2.2)
Yes	Yes	53	73	2.2 (1.5 to 3.4)
	Factor VIII > 153%
No	No	221	627	1 (reference)	+27% (−44% to +99%)
No	Yes	87	151	1.6 (1.1 to 2.1)
Yes	No	69	140	1.3 (0.9 to 1.9)
Yes	Yes	50	59	2.2 (1.4 to 3.4)
	Factor V Leiden†
No	No	278	760	1 (reference)	−31% (−204% to +142%)
No	Yes	30	20	4.1 (2.2 to 7.4)
Yes	No	105	185	1.5 (1.1 to 2.0)
Yes	Yes	13	10	3.7 (1.6 to 8.6)
	Prothrombin 20210A†
No	No	299	763	1 (reference)	+54% (−62% to +170%)
No	Yes	11	17	1.6 (0.7 to 3.4)
Yes	No	114	194	1.4 (1.1 to 1.9)
Yes	Yes	4	3	3.2 (0.7 to 14.5)

Factor XI > 157% (top quintile)	Additional risk factor*	No. of cases	No. of controls	OR (95% CI)†	RERI % (95% CI)
	D-dimer > 0.56 ng/mL
No	No	195	594	1 (reference)	−7% (−94% to +80%)
No	Yes	134	230	1.8 (1.3 to 2.4)
Yes	No	74	132	1.5 (1.1 to 2.2)
Yes	Yes	53	73	2.2 (1.5 to 3.4)
	Factor VIII > 153%
No	No	221	627	1 (reference)	+27% (−44% to +99%)
No	Yes	87	151	1.6 (1.1 to 2.1)
Yes	No	69	140	1.3 (0.9 to 1.9)
Yes	Yes	50	59	2.2 (1.4 to 3.4)
	Factor V Leiden†
No	No	278	760	1 (reference)	−31% (−204% to +142%)
No	Yes	30	20	4.1 (2.2 to 7.4)
Yes	No	105	185	1.5 (1.1 to 2.0)
Yes	Yes	13	10	3.7 (1.6 to 8.6)
	Prothrombin 20210A†
No	No	299	763	1 (reference)	+54% (−62% to +170%)
No	Yes	11	17	1.6 (0.7 to 3.4)
Yes	No	114	194	1.4 (1.1 to 1.9)
Yes	Yes	4	3	3.2 (0.7 to 14.5)

Defined as top tertile of D-dimer, top quartile of factor VIII, and heterozygotes plus homozygotes for each mutation.

Adjusted for age, race, sex, study, BMI, and diabetes.