Mcl-1 levels and relationship to risk factors and outcome measures
| Variable . | Mcl-1 levels . | P . | |
|---|---|---|---|
| < 0.85, no. (%) . | ≥ 0.85, no. (%) . | ||
| Rai stage | .66 | ||
| Low | 1 (4) | 2 (9) | |
| Intermediate | 12 (43) | 10 (46) | |
| High | 15 (54) | 10 (46) | |
| Sex | .30 | ||
| Male | 24 (86) | 16 (73) | |
| Female | 4 (14) | 6 (27) | |
| Age, y | .22 | ||
| < 70 | 18 (64) | 18 (82) | |
| ≥ 70 | 10 (36) | 4 (18) | |
| ECOG PS | .42 | ||
| 0 | 18 (64) | 10 (46) | |
| 1 | 9 (32) | 9 (41) | |
| 2 | 1 (4) | 2 (9) | |
| 3 | 0 (0) | 1 (5) | |
| CD38 (> 30) | 10 (36) | 6 (27) | .56 |
| ZAP-70+ cells (> 20) | 7 (32) | 7 (33) | .92 |
| IgVH status unmutated (> 98) | 19 (68) | 16 (76) | .75 |
| FISH | .82* | ||
| Normal | 2 (7) | 2 (9) | |
| +12 | 8 (29) | 3 (14) | |
| 11q− | 6 (21) | 6 (27) | |
| 17p− | 1 (4) | 1 (5) | |
| 6q− | 0 (0) | 1 (5) | |
| 13q− | 10 (36) | 9 (41) | |
| Other | 1 (4) | 0 (0) | |
| No. of genetic defects | .37* | ||
| 0 | 2 (7) | 2 (9) | |
| 1 | 13 (46) | 15 (68) | |
| 2+ | 13 (46) | 5 (23) | |
| Bone marrow pattern | .37 | ||
| Diffuse | 9 (39) | 11 (55) | |
| Not diffuse | 14 (61) | 9 (45) | |
| Outcome measures | |||
| MRD negative | 13 (57) | 4 (19) | .01* |
| Responders | 23 | 19 | .16 |
| CR | 15 (65) | 7 (37) | |
| nPR | 5 (22) | 6 (32) | |
| PR | 3 (13) | 6 (32) | |
| Median PFS | 50.8 mo | 18.7 mo | .02 |
| Variable . | Mcl-1 levels . | P . | |
|---|---|---|---|
| < 0.85, no. (%) . | ≥ 0.85, no. (%) . | ||
| Rai stage | .66 | ||
| Low | 1 (4) | 2 (9) | |
| Intermediate | 12 (43) | 10 (46) | |
| High | 15 (54) | 10 (46) | |
| Sex | .30 | ||
| Male | 24 (86) | 16 (73) | |
| Female | 4 (14) | 6 (27) | |
| Age, y | .22 | ||
| < 70 | 18 (64) | 18 (82) | |
| ≥ 70 | 10 (36) | 4 (18) | |
| ECOG PS | .42 | ||
| 0 | 18 (64) | 10 (46) | |
| 1 | 9 (32) | 9 (41) | |
| 2 | 1 (4) | 2 (9) | |
| 3 | 0 (0) | 1 (5) | |
| CD38 (> 30) | 10 (36) | 6 (27) | .56 |
| ZAP-70+ cells (> 20) | 7 (32) | 7 (33) | .92 |
| IgVH status unmutated (> 98) | 19 (68) | 16 (76) | .75 |
| FISH | .82* | ||
| Normal | 2 (7) | 2 (9) | |
| +12 | 8 (29) | 3 (14) | |
| 11q− | 6 (21) | 6 (27) | |
| 17p− | 1 (4) | 1 (5) | |
| 6q− | 0 (0) | 1 (5) | |
| 13q− | 10 (36) | 9 (41) | |
| Other | 1 (4) | 0 (0) | |
| No. of genetic defects | .37* | ||
| 0 | 2 (7) | 2 (9) | |
| 1 | 13 (46) | 15 (68) | |
| 2+ | 13 (46) | 5 (23) | |
| Bone marrow pattern | .37 | ||
| Diffuse | 9 (39) | 11 (55) | |
| Not diffuse | 14 (61) | 9 (45) | |
| Outcome measures | |||
| MRD negative | 13 (57) | 4 (19) | .01* |
| Responders | 23 | 19 | .16 |
| CR | 15 (65) | 7 (37) | |
| nPR | 5 (22) | 6 (32) | |
| PR | 3 (13) | 6 (32) | |
| Median PFS | 50.8 mo | 18.7 mo | .02 |
Exact P value.