The expression of 3 genes was associated with methotrexate polyglutamate (MTXPG) accumulation after excluding patients (n = 15) with extra copies of chromosome 18 from the analysis
| Gene symbol . | Description . | r (P value) expression vs CNV analysis (n = 82) . | r (P value) expression vs MTXPG analysis (n = 145) . | r (P value) expression vs MTXPGs in those with > 80% blasts (n = 128) . | r (P value) adjusted expression vs MTXPG analysis (n = 130) . |
|---|---|---|---|---|---|
| IMPA2 | Inositol(myo)-1 (or 4)-monophosphatase 2 | 0.34 (.001) | 0.25 (.003) | 0.28 (.002) | 0.19 (.058) |
| PHLPP | PH domain and leucine-rich repeat protein phosphatase | 0.24 (.020) | 0.28 (.001) | 0.24 (.007) | 0.27 (.021) |
| TYMS | Thymidylate synthetase | 0.21 (.043) | 0.28 (.001) | 0.25 (.004) | 0.26 (.009) |
| Gene symbol . | Description . | r (P value) expression vs CNV analysis (n = 82) . | r (P value) expression vs MTXPG analysis (n = 145) . | r (P value) expression vs MTXPGs in those with > 80% blasts (n = 128) . | r (P value) adjusted expression vs MTXPG analysis (n = 130) . |
|---|---|---|---|---|---|
| IMPA2 | Inositol(myo)-1 (or 4)-monophosphatase 2 | 0.34 (.001) | 0.25 (.003) | 0.28 (.002) | 0.19 (.058) |
| PHLPP | PH domain and leucine-rich repeat protein phosphatase | 0.24 (.020) | 0.28 (.001) | 0.24 (.007) | 0.27 (.021) |
| TYMS | Thymidylate synthetase | 0.21 (.043) | 0.28 (.001) | 0.25 (.004) | 0.26 (.009) |
The expression of these genes is also associated with chromosome 18 copy number variation (CNV).