Nonhematologic toxicities (frequency 10% or more of patients)
| Toxicity . | Clofarabine, n = 16 . | Clofarabine plus LD cytarabine, n = 54 . | ||
|---|---|---|---|---|
| Grade 2 or lower, no. (%) . | Grade 3 or higher, no. (%) . | Grade 2 or lower, no. (%) . | Grade 3 or higher, no. (%) . | |
| Diarrhea | 12 (75) | 45 (83) | 3 (6) | |
| Nausea | 12 (81) | 39 (72) | ||
| Hyperbilirubinemia | 4 (25) | 6 (38) | 35 (65) | 14 (26) |
| Mucositis | 2 (13) | 1 (6) | 24 (44) | |
| SGPT ↑ | 6 (38) | 4 (25) | 29 (54) | 6 (11) |
| Skin rashes | 7 (44) | 2 (13) | 27 (50) | 10 (19) |
| Headache | 6 (38) | 27 (50) | ||
| Emesis | 9 (56) | 27 (50) | ||
| Edema | 6 (38) | 29 (35) | ||
| SGOT ↑ | 2 (13) | 3 (19) | 18 (33) | x (13) |
| Anorexia | 3 (19) | 16 (30) | ||
| Alkaline phosphatase ↑ | 3 (19) | 15 (28) | 1 (2) | |
| Creatinine ↑ | 3 (19) | 2 (13) | 11 (20) | 3 (6) |
| Acute renal failure | 3 (19) | 8 (15) | ||
| Fatigue | 3 (19) | 9 (17) | 1 (2) | |
| Atrial fibrillation | 1 (6) | 2 (13) | 6 (11) | 3 (6) |
| Hand-foot syndrome | 2 (13) | 7 (13) | ||
| Facial flushing | 1 (6) | 7 (13) | ||
| Pruritus | 2 (13) | 5 (9) | ||
| Chest tightness | 6 (11) | |||
| Toxicity . | Clofarabine, n = 16 . | Clofarabine plus LD cytarabine, n = 54 . | ||
|---|---|---|---|---|
| Grade 2 or lower, no. (%) . | Grade 3 or higher, no. (%) . | Grade 2 or lower, no. (%) . | Grade 3 or higher, no. (%) . | |
| Diarrhea | 12 (75) | 45 (83) | 3 (6) | |
| Nausea | 12 (81) | 39 (72) | ||
| Hyperbilirubinemia | 4 (25) | 6 (38) | 35 (65) | 14 (26) |
| Mucositis | 2 (13) | 1 (6) | 24 (44) | |
| SGPT ↑ | 6 (38) | 4 (25) | 29 (54) | 6 (11) |
| Skin rashes | 7 (44) | 2 (13) | 27 (50) | 10 (19) |
| Headache | 6 (38) | 27 (50) | ||
| Emesis | 9 (56) | 27 (50) | ||
| Edema | 6 (38) | 29 (35) | ||
| SGOT ↑ | 2 (13) | 3 (19) | 18 (33) | x (13) |
| Anorexia | 3 (19) | 16 (30) | ||
| Alkaline phosphatase ↑ | 3 (19) | 15 (28) | 1 (2) | |
| Creatinine ↑ | 3 (19) | 2 (13) | 11 (20) | 3 (6) |
| Acute renal failure | 3 (19) | 8 (15) | ||
| Fatigue | 3 (19) | 9 (17) | 1 (2) | |
| Atrial fibrillation | 1 (6) | 2 (13) | 6 (11) | 3 (6) |
| Hand-foot syndrome | 2 (13) | 7 (13) | ||
| Facial flushing | 1 (6) | 7 (13) | ||
| Pruritus | 2 (13) | 5 (9) | ||
| Chest tightness | 6 (11) | |||