Table 3 Definition of clinicohematologic... | American Society of Hematology

Table 3

Definition of clinicohematologic response in ET and PV

Response grade	Definition
Response grade	Essential thrombocythemia	Polycythemia vera
Complete response	(1) Platelet count ≤ 400 × 10⁹/L, AND (2) no disease-related symptoms,* AND (3) normal spleen size on imaging, AND (4) white blood cell count ≤ 10 × 10⁹/L	(1) Hematocrit < 45% without phlebotomy AND (2) platelet count ≤ 400 × 10⁹/L AND (3) white blood cell count ≤ 10 × 10⁹/L, AND (4) normal spleen size on imaging AND (5) no disease-related symptoms*
Partial response	In patients who do not fulfill the criteria for complete response, platelet count ≤ 600 × 10⁹/L OR decrease > 50% from baseline	In patients who do not fulfill the criteria for complete response, hematocrit < 45% without phlebotomy ORresponse in 3 or more of the other criteria
No response	Any response that does not satisfy partial response	Any response that does not satisfy partial response

Response grade	Definition
Response grade	Essential thrombocythemia	Polycythemia vera
Complete response	(1) Platelet count ≤ 400 × 10⁹/L, AND (2) no disease-related symptoms,* AND (3) normal spleen size on imaging, AND (4) white blood cell count ≤ 10 × 10⁹/L	(1) Hematocrit < 45% without phlebotomy AND (2) platelet count ≤ 400 × 10⁹/L AND (3) white blood cell count ≤ 10 × 10⁹/L, AND (4) normal spleen size on imaging AND (5) no disease-related symptoms*
Partial response	In patients who do not fulfill the criteria for complete response, platelet count ≤ 600 × 10⁹/L OR decrease > 50% from baseline	In patients who do not fulfill the criteria for complete response, hematocrit < 45% without phlebotomy ORresponse in 3 or more of the other criteria
No response	Any response that does not satisfy partial response	Any response that does not satisfy partial response

Disease-related symptoms: microvascular disturbances, pruritus, headache.