Table 2 Core set of conceptual criteria... | American Society of Hematology

Table 2

Core set of conceptual criteria to be used for defining response in ET and PV

Response category/essential thrombocythemia	Response category/polycythemia vera
Clinicohematologic
Reduction/normalization of platelet count	Reduction of phlebotomy requirement to maintain the hematocrit at the target level
Resolution of disease-related symptoms*	Reduction/normalization of platelet count
Reduction/normalization of splenomegaly on imaging	Reduction/normalization of white blood cell count
Reduction/normalization of white blood cell count	Reduction/normalization of splenomegaly on imaging
	Resolution of disease-related symptoms*
Molecular
Reduction of any specific molecular abnormalities	Reduction of any specific molecular abnormalities
Histologic
Bone marrow histologic remission defined as the disappearance of megakaryocyte hyperplasia	Bone marrow histologic remission defined as the presence of age-adjusted normocellularity and no reticulin fibrosis

Response category/essential thrombocythemia	Response category/polycythemia vera
Clinicohematologic
Reduction/normalization of platelet count	Reduction of phlebotomy requirement to maintain the hematocrit at the target level
Resolution of disease-related symptoms*	Reduction/normalization of platelet count
Reduction/normalization of splenomegaly on imaging	Reduction/normalization of white blood cell count
Reduction/normalization of white blood cell count	Reduction/normalization of splenomegaly on imaging
	Resolution of disease-related symptoms*
Molecular
Reduction of any specific molecular abnormalities	Reduction of any specific molecular abnormalities
Histologic
Bone marrow histologic remission defined as the disappearance of megakaryocyte hyperplasia	Bone marrow histologic remission defined as the presence of age-adjusted normocellularity and no reticulin fibrosis

Disease-related symptoms: microvascular disturbances, pruritus, headache.